Skip to main content

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

Publication ,  Journal Article
Dixon-Suen, SC; Nagle, CM; Thrift, AP; Pharoah, PDP; Ewing, A; Pearce, CL; Zheng, W; Australian Ovarian Cancer Study Group, ; Chenevix-Trench, G ...
Published in: Br J Cancer
April 2018

BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

April 2018

Volume

118

Issue

8

Start / End Page

1123 / 1129

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Mendelian Randomization Analysis
  • Humans
  • Geography
  • Genetic Predisposition to Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dixon-Suen, S. C., Nagle, C. M., Thrift, A. P., Pharoah, P. D. P., Ewing, A., Pearce, C. L., … Ovarian Cancer Association Consortium, . (2018). Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. Br J Cancer, 118(8), 1123–1129. https://doi.org/10.1038/s41416-018-0011-3
Dixon-Suen, Suzanne C., Christina M. Nagle, Aaron P. Thrift, Paul D. P. Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, et al. “Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.Br J Cancer 118, no. 8 (April 2018): 1123–29. https://doi.org/10.1038/s41416-018-0011-3.
Dixon-Suen SC, Nagle CM, Thrift AP, Pharoah PDP, Ewing A, Pearce CL, et al. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. Br J Cancer. 2018 Apr;118(8):1123–9.
Dixon-Suen, Suzanne C., et al. “Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.Br J Cancer, vol. 118, no. 8, Apr. 2018, pp. 1123–29. Pubmed, doi:10.1038/s41416-018-0011-3.
Dixon-Suen SC, Nagle CM, Thrift AP, Pharoah PDP, Ewing A, Pearce CL, Zheng W, Australian Ovarian Cancer Study Group, Chenevix-Trench G, Fasching PA, Beckmann MW, Lambrechts D, Vergote I, Lambrechts S, Van Nieuwenhuysen E, Rossing MA, Doherty JA, Wicklund KG, Chang-Claude J, Jung AY, Moysich KB, Odunsi K, Goodman MT, Wilkens LR, Thompson PJ, Shvetsov YB, Dörk T, Park-Simon T-W, Hillemanns P, Bogdanova N, Butzow R, Nevanlinna H, Pelttari LM, Leminen A, Modugno F, Ness RB, Edwards RP, Kelley JL, Heitz F, du Bois A, Harter P, Schwaab I, Karlan BY, Lester J, Orsulic S, Rimel BJ, Kjær SK, Høgdall E, Jensen A, Goode EL, Fridley BL, Cunningham JM, Winham SJ, Giles GG, Bruinsma F, Milne RL, Southey MC, Hildebrandt MAT, Wu X, Lu KH, Liang D, Levine DA, Bisogna M, Schildkraut JM, Berchuck A, Cramer DW, Terry KL, Bandera EV, Olson SH, Salvesen HB, Thomsen LCV, Kopperud RK, Bjorge L, Kiemeney LA, Massuger LFAG, Pejovic T, Bruegl A, Cook LS, Le ND, Swenerton KD, Brooks-Wilson A, Kelemen LE, Lubiński J, Huzarski T, Gronwald J, Menkiszak J, Wentzensen N, Brinton L, Yang H, Lissowska J, Høgdall CK, Lundvall L, Song H, Tyrer JP, Campbell I, Eccles D, Paul J, Glasspool R, Siddiqui N, Whittemore AS, Sieh W, McGuire V, Rothstein JH, Narod SA, Phelan C, Risch HA, McLaughlin JR, Anton-Culver H, Ziogas A, Menon U, Gayther SA, Ramus SJ, Gentry-Maharaj A, Wu AH, Pike MC, Tseng C-C, Kupryjanczyk J, Dansonka-Mieszkowska A, Budzilowska A, Rzepecka IK, Webb PM, Ovarian Cancer Association Consortium. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. Br J Cancer. 2018 Apr;118(8):1123–1129.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

April 2018

Volume

118

Issue

8

Start / End Page

1123 / 1129

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Mendelian Randomization Analysis
  • Humans
  • Geography
  • Genetic Predisposition to Disease
  • Female