In situ forming injectable hydrogels for drug delivery and wound repair.

Journal Article (Review;Journal Article)

Hydrogels have been utilized in regenerative applications for many decades because of their biocompatibility and similarity in structure to the native extracellular matrix. Initially, these materials were formed outside of the patient and implanted using invasive surgical techniques. However, advances in synthetic chemistry and materials science have now provided researchers with a library of techniques whereby hydrogel formation can occur in situ upon delivery through standard needles. This provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body. In this review, we highlight these injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair.

Full Text

Duke Authors

Cited Authors

  • Dimatteo, R; Darling, NJ; Segura, T

Published Date

  • March 2018

Published In

Volume / Issue

  • 127 /

Start / End Page

  • 167 - 184

PubMed ID

  • 29567395

Pubmed Central ID

  • PMC6003852

Electronic International Standard Serial Number (EISSN)

  • 1872-8294

International Standard Serial Number (ISSN)

  • 0169-409X

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2018.03.007


  • eng