Skip to main content
Journal cover image

Impact of atopy on risk of glioma: a Mendelian randomisation study.

Publication ,  Journal Article
Disney-Hogg, L; Cornish, AJ; Sud, A; Law, PJ; Kinnersley, B; Jacobs, DI; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB ...
Published in: BMC Med
March 15, 2018

BACKGROUND: An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to assess the relationship with glioma risk using Mendelian randomisation (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. METHODS: Two-sample MR was undertaken using genome-wide association study data. We used single nucleotide polymorphisms (SNPs) associated with atopic dermatitis, asthma and hay fever, IgE levels, and self-reported allergy as instrumental variables. We calculated MR estimates for the odds ratio (OR) for each risk factor with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighting (IVW), maximum likelihood estimation (MLE), weighted median estimate (WME) and mode-based estimate (MBE) methods. Violation of MR assumptions due to directional pleiotropy were sought using MR-Egger regression and HEIDI-outlier analysis. RESULTS: Under IVW, MLE, WME and MBE methods, associations between glioma risk with asthma and hay fever, self-reported allergy and IgE levels were non-significant. An inverse relationship between atopic dermatitis and glioma risk was found by IVW (OR 0.96, 95% confidence interval (CI) 0.93-1.00, P = 0.041) and MLE (OR 0.96, 95% CI 0.94-0.99, P = 0.003), but not by WME (OR 0.96, 95% CI 0.91-1.01, P = 0.114) or MBE (OR 0.97, 95% CI 0.92-1.02, P = 0.194). CONCLUSIONS: Our investigation does not provide strong evidence for relationship between atopy and the risk of developing glioma, but findings do not preclude a small effect in relation to atopic dermatitis. Our analysis also serves to illustrate the value of using several MR methods to derive robust conclusions.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

BMC Med

DOI

EISSN

1741-7015

Publication Date

March 15, 2018

Volume

16

Issue

1

Start / End Page

42

Location

England

Related Subject Headings

  • Risk Factors
  • Mendelian Randomization Analysis
  • Humans
  • Glioma
  • Genotype
  • Genome-Wide Association Study
  • General & Internal Medicine
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Disney-Hogg, L., Cornish, A. J., Sud, A., Law, P. J., Kinnersley, B., Jacobs, D. I., … Houlston, R. S. (2018). Impact of atopy on risk of glioma: a Mendelian randomisation study. BMC Med, 16(1), 42. https://doi.org/10.1186/s12916-018-1027-5
Disney-Hogg, Linden, Alex J. Cornish, Amit Sud, Philip J. Law, Ben Kinnersley, Daniel I. Jacobs, Quinn T. Ostrom, et al. “Impact of atopy on risk of glioma: a Mendelian randomisation study.BMC Med 16, no. 1 (March 15, 2018): 42. https://doi.org/10.1186/s12916-018-1027-5.
Disney-Hogg L, Cornish AJ, Sud A, Law PJ, Kinnersley B, Jacobs DI, et al. Impact of atopy on risk of glioma: a Mendelian randomisation study. BMC Med. 2018 Mar 15;16(1):42.
Disney-Hogg, Linden, et al. “Impact of atopy on risk of glioma: a Mendelian randomisation study.BMC Med, vol. 16, no. 1, Mar. 2018, p. 42. Pubmed, doi:10.1186/s12916-018-1027-5.
Disney-Hogg L, Cornish AJ, Sud A, Law PJ, Kinnersley B, Jacobs DI, Ostrom QT, Labreche K, Eckel-Passow JE, Armstrong GN, Claus EB, Il’yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Schoemaker MJ, Simon M, Hoffmann P, Nöthen MM, Jöckel K-H, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS. Impact of atopy on risk of glioma: a Mendelian randomisation study. BMC Med. 2018 Mar 15;16(1):42.
Journal cover image

Published In

BMC Med

DOI

EISSN

1741-7015

Publication Date

March 15, 2018

Volume

16

Issue

1

Start / End Page

42

Location

England

Related Subject Headings

  • Risk Factors
  • Mendelian Randomization Analysis
  • Humans
  • Glioma
  • Genotype
  • Genome-Wide Association Study
  • General & Internal Medicine
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences