Validating functional data analysis measures from 24-h actigraphy data


Journal Article

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. The timing of sleep and wakefulness are under the influence of the circadian pacemaker in the suprachiasmatic nucleus, and the set-point for the circadian pacemaker is revealed by the time of onset of the secretion of melatonin under dim light conditions (DLMO). Measuring DLMO is time intensive and requires biochemical assays; hence it would be desirable to develop simpler alternatives to DLMO measurement that would otherwise provide similar information about health and illness. Continuous, multi-day measurement of actigraphy can be processed to reveal underlying features such as the time of greatest activity (acrophase), or the time of least activity (bathyphase). In this paper, we explore the calculation of the acrophase and bathyphase using a statistical approach called functional data analysis (FDA), and validated the FDA-calculated bathyphase by correlating it with morningness–eveningness self-reports from 47 depressed adults.

Full Text

Duke Authors

Cited Authors

  • Lundeen, J; McCall, WV; Krystal, A; Looney, S

Published Date

  • September 3, 2018

Published In

Volume / Issue

  • 49 / 5

Start / End Page

  • 797 - 810

Electronic International Standard Serial Number (EISSN)

  • 1744-4179

International Standard Serial Number (ISSN)

  • 0929-1016

Digital Object Identifier (DOI)

  • 10.1080/09291016.2018.1424771

Citation Source

  • Scopus