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Influence of obesity-related risk factors in the aetiology of glioma.

Publication ,  Journal Article
Disney-Hogg, L; Sud, A; Law, PJ; Cornish, AJ; Kinnersley, B; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D ...
Published in: Br J Cancer
April 2018

BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

April 2018

Volume

118

Issue

7

Start / End Page

1020 / 1027

Location

England

Related Subject Headings

  • Waist-Hip Ratio
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Obesity
  • Middle Aged
  • Male
  • Lipid Metabolism
  • Insulin Resistance
  • Humans
 

Citation

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Chicago
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Disney-Hogg, L., Sud, A., Law, P. J., Cornish, A. J., Kinnersley, B., Ostrom, Q. T., … Houlston, R. S. (2018). Influence of obesity-related risk factors in the aetiology of glioma. Br J Cancer, 118(7), 1020–1027. https://doi.org/10.1038/s41416-018-0009-x
Disney-Hogg, Linden, Amit Sud, Philip J. Law, Alex J. Cornish, Ben Kinnersley, Quinn T. Ostrom, Karim Labreche, et al. “Influence of obesity-related risk factors in the aetiology of glioma.Br J Cancer 118, no. 7 (April 2018): 1020–27. https://doi.org/10.1038/s41416-018-0009-x.
Disney-Hogg L, Sud A, Law PJ, Cornish AJ, Kinnersley B, Ostrom QT, et al. Influence of obesity-related risk factors in the aetiology of glioma. Br J Cancer. 2018 Apr;118(7):1020–7.
Disney-Hogg, Linden, et al. “Influence of obesity-related risk factors in the aetiology of glioma.Br J Cancer, vol. 118, no. 7, Apr. 2018, pp. 1020–27. Pubmed, doi:10.1038/s41416-018-0009-x.
Disney-Hogg L, Sud A, Law PJ, Cornish AJ, Kinnersley B, Ostrom QT, Labreche K, Eckel-Passow JE, Armstrong GN, Claus EB, Il’yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Swerdlow AJ, Simon M, Hoffmann P, Nöthen MM, Jöckel K-H, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS. Influence of obesity-related risk factors in the aetiology of glioma. Br J Cancer. 2018 Apr;118(7):1020–1027.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

April 2018

Volume

118

Issue

7

Start / End Page

1020 / 1027

Location

England

Related Subject Headings

  • Waist-Hip Ratio
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Obesity
  • Middle Aged
  • Male
  • Lipid Metabolism
  • Insulin Resistance
  • Humans