A transformation from temporal to ensemble coding in a model of piriform cortex.

Published online

Journal Article

Different coding strategies are used to represent odor information at various stages of the mammalian olfactory system. A temporal latency code represents odor identity in olfactory bulb (OB), but this temporal information is discarded in piriform cortex (PCx) where odor identity is instead encoded through ensemble membership. We developed a spiking PCx network model to understand how this transformation is implemented. In the model, the impact of OB inputs activated earliest after inhalation is amplified within PCx by diffuse recurrent collateral excitation, which then recruits strong, sustained feedback inhibition that suppresses the impact of later-responding glomeruli. We model increasing odor concentrations by decreasing glomerulus onset latencies while preserving their activation sequences. This produces a multiplexed cortical odor code in which activated ensembles are robust to concentration changes while concentration information is encoded through population synchrony. Our model demonstrates how PCx circuitry can implement multiplexed ensemble-identity/temporal-concentration odor coding.

Full Text

Duke Authors

Cited Authors

  • Stern, M; Bolding, KA; Abbott, LF; Franks, KM

Published Date

  • March 29, 2018

Published In

Volume / Issue

  • 7 /

PubMed ID

  • 29595470

Pubmed Central ID

  • 29595470

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.34831

Language

  • eng

Conference Location

  • England