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A transformation from temporal to ensemble coding in a model of piriform cortex.

Publication ,  Journal Article
Stern, M; Bolding, KA; Abbott, LF; Franks, KM
Published in: Elife
March 29, 2018

Different coding strategies are used to represent odor information at various stages of the mammalian olfactory system. A temporal latency code represents odor identity in olfactory bulb (OB), but this temporal information is discarded in piriform cortex (PCx) where odor identity is instead encoded through ensemble membership. We developed a spiking PCx network model to understand how this transformation is implemented. In the model, the impact of OB inputs activated earliest after inhalation is amplified within PCx by diffuse recurrent collateral excitation, which then recruits strong, sustained feedback inhibition that suppresses the impact of later-responding glomeruli. We model increasing odor concentrations by decreasing glomerulus onset latencies while preserving their activation sequences. This produces a multiplexed cortical odor code in which activated ensembles are robust to concentration changes while concentration information is encoded through population synchrony. Our model demonstrates how PCx circuitry can implement multiplexed ensemble-identity/temporal-concentration odor coding.

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Published In

Elife

DOI

EISSN

2050-084X

Publication Date

March 29, 2018

Volume

7

Location

England

Related Subject Headings

  • Time
  • Piriform Cortex
  • Olfactory Perception
  • Odorants
  • Models, Neurological
  • Mice
  • Male
  • Female
  • Electroencephalography
  • Animals
 

Citation

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Stern, M., Bolding, K. A., Abbott, L. F., & Franks, K. M. (2018). A transformation from temporal to ensemble coding in a model of piriform cortex. Elife, 7. https://doi.org/10.7554/eLife.34831
Stern, Merav, Kevin A. Bolding, L. F. Abbott, and Kevin M. Franks. “A transformation from temporal to ensemble coding in a model of piriform cortex.Elife 7 (March 29, 2018). https://doi.org/10.7554/eLife.34831.
Stern M, Bolding KA, Abbott LF, Franks KM. A transformation from temporal to ensemble coding in a model of piriform cortex. Elife. 2018 Mar 29;7.
Stern, Merav, et al. “A transformation from temporal to ensemble coding in a model of piriform cortex.Elife, vol. 7, Mar. 2018. Pubmed, doi:10.7554/eLife.34831.
Stern M, Bolding KA, Abbott LF, Franks KM. A transformation from temporal to ensemble coding in a model of piriform cortex. Elife. 2018 Mar 29;7.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

March 29, 2018

Volume

7

Location

England

Related Subject Headings

  • Time
  • Piriform Cortex
  • Olfactory Perception
  • Odorants
  • Models, Neurological
  • Mice
  • Male
  • Female
  • Electroencephalography
  • Animals