Safety, Effectiveness and Exposure-response of Micafungin in Infants: Application of an Established Pharmacokinetics Model to Electronic Health Records.


Journal Article

Micafungin is used off-label in the United States to treat invasive candidiasis in neonates. We used an established pharmacokinetic model to determine micafungin exposures for 46 courses in 39 hospitalized infants. In this small cohort of infants, micafungin exposure was not associated with laboratory markers of liver toxicity, death or failure of microbiologic clearance.

Full Text

Duke Authors

Cited Authors

  • Rivera-Chaparro, ND; Ericson, J; Wu, H; Smith, PB; Clark, RH; Benjamin, DK; Cohen-Wolkowiez, M; Greenberg, RG

Published Date

  • February 2019

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • e26 - e28

PubMed ID

  • 29601453

Pubmed Central ID

  • 29601453

Electronic International Standard Serial Number (EISSN)

  • 1532-0987

Digital Object Identifier (DOI)

  • 10.1097/INF.0000000000002045


  • eng

Conference Location

  • United States