Postoperative Abdominal Adhesions: Clinical Significance and Advances in Prevention and Management.

Journal Article (Review;Journal Article)

Postoperative adhesions remain one of the more challenging issues in surgical practice. Although peritoneal adhesions occur after every abdominal operation, the density, time interval to develop symptoms, and clinical presentation are highly variable with no predictable patterns. Numerous studies have investigated the pathophysiology of postoperative adhesions both in vitro and in vivo. Factors such as type and location of adhesions, as well as timing and recurrence of adhesive obstruction remain unpredictable and poorly understood. Although the majority of postoperative adhesions are clinically silent, the consequences of adhesion formation can represent a lifelong problem including chronic abdominal pain, recurrent intestinal obstruction requiring multiple hospitalizations, and infertility. Moreover, adhesive disease can become a chronic medical condition with significant morbidity and no effective therapy. Despite recent advances in surgical techniques, there is no reliable strategy to manage postoperative adhesions. We herein review the pathophysiology and clinical significance of postoperative adhesions while highlighting current techniques of prevention and treatment.

Full Text

Duke Authors

Cited Authors

  • Moris, D; Chakedis, J; Rahnemai-Azar, AA; Wilson, A; Hennessy, MM; Athanasiou, A; Beal, EW; Argyrou, C; Felekouras, E; Pawlik, TM

Published Date

  • October 2017

Published In

Volume / Issue

  • 21 / 10

Start / End Page

  • 1713 - 1722

PubMed ID

  • 28685387

Electronic International Standard Serial Number (EISSN)

  • 1873-4626

International Standard Serial Number (ISSN)

  • 1091-255X

Digital Object Identifier (DOI)

  • 10.1007/s11605-017-3488-9


  • eng