Surgical Management of Non-small Cell Lung Cancer with Solitary Hematogenous Metastases.
Published
Journal Article
The treatment of patients with solitary hematogenous metastases from non-small cell lung cancer (NSCLC) remains controversial, although numerous retrospective studies have reported favorable results for patients offered combined surgical therapy. Our aim was to determine the role of surgical resection in the management of NSCLC with solitary extrapulmonary metastases and to investigate for possible prognostic factors.Between January 2004 and December 2012, 12 patients with NSCLC, from two Institutions, underwent metastasectomy for their solitary metastatic lesion. Sites of metastases included brain (n=3), adrenal gland (n=6), thoracic wall (n=2) and diaphragm (n=1). All patients had undergone pulmonary resections for their primary NSCLC.Median survival for the entire cohort was 24.1 months, whereas 1- and 5-year survival rates were 73% and 39%, respectively. Patients with stage III intrathoracic disease had significantly worse survival than those with lower tumor stage. A tendency for adenocarcinomatous histology to positively affect survival was recognized, although it was proven not to be statistically significant.Despite the retrospective nature of our study and the small cohort size, it is emerging that combined surgical resection might offer patients with NSCLC with solitary hematogenous metastases a survival benefit. Limited intrathoracic disease and adenocarcinomatous histology might be associated with better outcomes.
Full Text
Duke Authors
Cited Authors
- Karagkiouzis, G; Spartalis, E; Moris, D; Patsouras, D; Athanasiou, A; Karathanasis, I; Verveniotis, A; Konstantinou, F; Kouerinis, IA; Potaris, K; Dimitroulis, D; Tomos, P
Published Date
- May 2017
Published In
Volume / Issue
- 31 / 3
Start / End Page
- 451 - 454
PubMed ID
- 28438878
Pubmed Central ID
- 28438878
Electronic International Standard Serial Number (EISSN)
- 1791-7549
International Standard Serial Number (ISSN)
- 0258-851X
Digital Object Identifier (DOI)
- 10.21873/invivo.11082
Language
- eng