Laparoscopic Splenectomy for Benign Hematological Disorders in Adults: A Systematic Review.

Journal Article (Systematic Review;Review;Journal Article)


Since its introduction in the early 1990s, laparoscopic splenectomy (LS) has gained worldwide acceptance for spleen removal, especially in hematological patients.


The present review summarizes the current knowledge and results of LS for the treatment of benign hematological diseases in adults.

Materials and methods

A MEDLINE/PubMed database research was performed using the terms: "laparoscopic splenectomy" OR "laparoscopy" OR "splenectomy" AND "hematological disorders" OR "hematological disease" OR "hematology" AND "adults" as key words. We set our analysis starting date as January 1st 2010 and the end date as December 31st 2016. We identified 247 relative articles. All the references from the identified articles were searched for relevant information.


Twenty-seven articles were deemed appropriate for our analysis. LS was found to be feasible and safe in the majority of patients with benign hematological disorders, with a mortality rate ranging from 0% to less than 4% and the postoperative complications rate from 0% to 35.7%. The conversion rate was also very low (4%) and response (complete or partial) was achieved in more than 80% of patients. Lateral approach with four trocars was the most commonly used approach with concommitant cholecystectomy being correlated with increased operative time and morbidity.


Current literature holds that whenever splenectomy is required for the treatment of hematological disorders in adults, a laparoscopic approach should be offered as the gold standard. However, to strengthen the clinical evidence in favor of LS, more high-quality clinical trials on several issues of the procedure are necessary.

Full Text

Duke Authors

Cited Authors

  • Moris, D; Dimitriou, N; Griniatsos, J

Published Date

  • May 2017

Published In

Volume / Issue

  • 31 / 3

Start / End Page

  • 291 - 302

PubMed ID

  • 28438854

Pubmed Central ID

  • PMC5461436

Electronic International Standard Serial Number (EISSN)

  • 1791-7549

International Standard Serial Number (ISSN)

  • 0258-851X

Digital Object Identifier (DOI)

  • 10.21873/invivo.11058


  • eng