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Tailoring the 'Perfect Fit' for Renal Transplant Recipients with End-stage Polycystic Kidney Disease: Indications and Timing of Native Nephrectomy.

Publication ,  Journal Article
Argyrou, C; Moris, D; Vernadakis, S
Published in: In vivo (Athens, Greece)
May 2017

The ideal timing of native nephrectomy in relation to kidney transplantation in patients with autosomal-dominant polycystic kidney disease (ADPKD) can be a very puzzling decision for transplant surgeons and remains a matter of debate. This review article aims to present current literature regarding this highly controversial issue.The MEDLINE/PubMed database was searched using "polycystic kidney disease", "renal/kidney transplantation" and "native nephrectomy" as key words. Our search was focused on the optimal timing of and indications for native nephrectomy in renal transplant recipients with ADPKD.In symptomatic cases, pre-transplant unilateral or bilateral native nephrectomy seems appropriate, in order to alleviate symptoms. In cases that are provided with the option of living-donor transplantation, the performance of the simultaneous procedure could be of benefit. When the principal indication of native nephrectomy is the creation of space for the renal allograft, various studies highlight the safety of the simultaneous approach of either unilateral or bilateral nephrectomy.No consensus exists on the appropriate timing for native nephrectomy in patients with ADPKD. Several issues to be addressed in the decision-making process are the importance of residual diuresis, the longer operative time along with the associated prolonged ischemia time and higher complication rate of the combined procedure.

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Published In

In vivo (Athens, Greece)

DOI

EISSN

1791-7549

ISSN

0258-851X

Publication Date

May 2017

Volume

31

Issue

3

Start / End Page

307 / 312

Related Subject Headings

  • Polycystic Kidney, Autosomal Dominant
  • Oncology & Carcinogenesis
  • Nephrectomy
  • Kidney Transplantation
  • Kidney Failure, Chronic
  • Kidney
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry
  • 3202 Clinical sciences
 

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Argyrou, C., Moris, D., & Vernadakis, S. (2017). Tailoring the 'Perfect Fit' for Renal Transplant Recipients with End-stage Polycystic Kidney Disease: Indications and Timing of Native Nephrectomy. In Vivo (Athens, Greece), 31(3), 307–312. https://doi.org/10.21873/invivo.11060
Argyrou, Chrysoula, Demetrios Moris, and Spyridon Vernadakis. “Tailoring the 'Perfect Fit' for Renal Transplant Recipients with End-stage Polycystic Kidney Disease: Indications and Timing of Native Nephrectomy.In Vivo (Athens, Greece) 31, no. 3 (May 2017): 307–12. https://doi.org/10.21873/invivo.11060.
Argyrou, Chrysoula, et al. “Tailoring the 'Perfect Fit' for Renal Transplant Recipients with End-stage Polycystic Kidney Disease: Indications and Timing of Native Nephrectomy.In Vivo (Athens, Greece), vol. 31, no. 3, May 2017, pp. 307–12. Epmc, doi:10.21873/invivo.11060.

Published In

In vivo (Athens, Greece)

DOI

EISSN

1791-7549

ISSN

0258-851X

Publication Date

May 2017

Volume

31

Issue

3

Start / End Page

307 / 312

Related Subject Headings

  • Polycystic Kidney, Autosomal Dominant
  • Oncology & Carcinogenesis
  • Nephrectomy
  • Kidney Transplantation
  • Kidney Failure, Chronic
  • Kidney
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3203 Dentistry
  • 3202 Clinical sciences