Skip to main content

De Novo Renal Cell Carcinoma of Native Kidneys in Renal Transplant Recipients: A Single-center Experience.

Publication ,  Journal Article
Moris, D; Kakavia, K; Argyrou, C; Garmpis, N; Bokos, J; Vernadakis, S; Diles, K; Sotirchos, G; Boletis, J; Zavos, G
Published in: Anticancer research
February 2017

The risk of renal cell carcinoma (RCC) development in renal transplant recipients is 15-100 times higher than in the general population. The majority of RCCs found in renal transplant recipients develop in the recipient's native kidneys, only 9% of tumors develop in the allograft itself. The mechanisms of development of RCC in native kidneys and renal allografts are not completely understood. We present our experience in renal transplant recipients with RCC of native kidneys providing valuable and clinically applicable treatment and follow-up data.The records of 2,173 patients who underwent renal transplantation in our Department between March 1983 and December 2015 were retrospectively reviewed. Using these data, we analyzed the incidence and types of post-transplant RCCs, as well as their clinical courses, focusing on native malignancies.We found 11 RCCs (0.5%) during the observation period in native kidneys. The mean (±SD) follow-up period was 50.54±32.80 months. Four patients died during this period (36.4%).Most RCCs in renal transplant recipients are low-stage, low-grade tumors with a favorable prognosis. Their diagnosis is usually incidental. RCC development in the native kidney of renal transplant recipients is an early event, frequently observed within 4 to 5 years after transplantation. The different natural history of these tumors is still undefined. Further research is needed to determine whether these differences are due to particular molecular pathways or to biases in relation to the mode of diagnosis.

Duke Scholars

Published In

Anticancer research

DOI

EISSN

1791-7530

ISSN

0250-7005

Publication Date

February 2017

Volume

37

Issue

2

Start / End Page

773 / 779

Related Subject Headings

  • Young Adult
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Kidney Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moris, D., Kakavia, K., Argyrou, C., Garmpis, N., Bokos, J., Vernadakis, S., … Zavos, G. (2017). De Novo Renal Cell Carcinoma of Native Kidneys in Renal Transplant Recipients: A Single-center Experience. Anticancer Research, 37(2), 773–779. https://doi.org/10.21873/anticanres.11376
Moris, Demetrios, Kiriaki Kakavia, Chrysoula Argyrou, Nikolaos Garmpis, John Bokos, Spyridon Vernadakis, Konstantinos Diles, Georgios Sotirchos, John Boletis, and Georgios Zavos. “De Novo Renal Cell Carcinoma of Native Kidneys in Renal Transplant Recipients: A Single-center Experience.Anticancer Research 37, no. 2 (February 2017): 773–79. https://doi.org/10.21873/anticanres.11376.
Moris D, Kakavia K, Argyrou C, Garmpis N, Bokos J, Vernadakis S, et al. De Novo Renal Cell Carcinoma of Native Kidneys in Renal Transplant Recipients: A Single-center Experience. Anticancer research. 2017 Feb;37(2):773–9.
Moris, Demetrios, et al. “De Novo Renal Cell Carcinoma of Native Kidneys in Renal Transplant Recipients: A Single-center Experience.Anticancer Research, vol. 37, no. 2, Feb. 2017, pp. 773–79. Epmc, doi:10.21873/anticanres.11376.
Moris D, Kakavia K, Argyrou C, Garmpis N, Bokos J, Vernadakis S, Diles K, Sotirchos G, Boletis J, Zavos G. De Novo Renal Cell Carcinoma of Native Kidneys in Renal Transplant Recipients: A Single-center Experience. Anticancer research. 2017 Feb;37(2):773–779.

Published In

Anticancer research

DOI

EISSN

1791-7530

ISSN

0250-7005

Publication Date

February 2017

Volume

37

Issue

2

Start / End Page

773 / 779

Related Subject Headings

  • Young Adult
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Kidney Neoplasms