Parenchymal-sparing Hepatectomy as the New Doctrine in the Treatment of Liver-metastatic Colorectal Disease: Beyond Oncological Outcomes.

Journal Article (Review;Journal Article)

Colorectal cancer is one of the leading causes of mortality in the Western world. Half of patients with colorectal cancer will develop liver-metastatic (CLM) disease, with fewer than 30% having surgically resectable disease at diagnosis. It is well established in the literature that major hepatectomy offers a high rate of R0 resection, however, with concommitant increased rates of mortality and morbidity. Emerging literature during the past two decades has demonstrated the potential superiority of parenchymal-sparing hepatectomy (PSH) in treating CLM disease in terms of oncological outcomes, survival and re-operation in cases of recurrence (salvageability). To date, no data regarding the evaluation of quality of life and cost after PSH have been published. PSH seems to be correlated with less mortality and morbidity, which can be translated in lower re-admission rates, better quality of life and, therefore, reduced relevant cost. Prospective studies and clinical trials evaluating the multiple beneficial role of a PSH surgical strategy in CLM disease are mandatory to support or reject the emerging belief that PSH could be the gold standard of treatment of CLM disease.

Full Text

Duke Authors

Cited Authors

  • Moris, D; Dimitroulis, D; Vernadakis, S; Papalampros, A; Spartalis, E; Petrou, A; Pawlik, TM; Felekouras, E

Published Date

  • January 2017

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 9 - 14

PubMed ID

  • 28011468

Electronic International Standard Serial Number (EISSN)

  • 1791-7530

International Standard Serial Number (ISSN)

  • 0250-7005

Digital Object Identifier (DOI)

  • 10.21873/anticanres.11283


  • eng