The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives


Journal Article (Review)

© 2016 S. Karger GmbH, Freiburg. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have received considerable interest as potential chemopreventive agents. The aim of this review is to summarize the accumulated knowledge on the effect of NSAIDs on breast cancer incidence and natural history, and the underlying pathophysiology. NSAIDs mainly block inflammation by inhibiting cyclooxygenase enzymes, leading to lower prostaglandin synthesis. The latter has been reported to affect breast cancer risk through hormonal and inflammation-related pathways. Intensity, dose, frequency, duration, and timing of administration may also be significant. There is currently enough evidence to support a role of NSAIDs in breast cancer prevention and relapse, which deserves further large-scale experimental and clinical investigation.

Full Text

Duke Authors

Cited Authors

  • Moris, D; Kontos, M; Spartalis, E; Fentiman, IS

Published Date

  • October 1, 2016

Published In

Volume / Issue

  • 11 / 5

Start / End Page

  • 339 - 344

Electronic International Standard Serial Number (EISSN)

  • 1661-3805

International Standard Serial Number (ISSN)

  • 1661-3791

Digital Object Identifier (DOI)

  • 10.1159/000452315

Citation Source

  • Scopus