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Surgical Dead End in a Renal Transplant Recipient Associated With a Rare Thrombohemorrhagic Syndrome.

Publication ,  Journal Article
Vailas, MG; Vernadakis, S; Moris, D; Zavos, G
Published in: Transplantation proceedings
October 2015

Primary breast angiosarcoma is an extremely rare malignancy. Association of this type of tumor with Kasabach-Merritt syndrome has only been reported in 3 cases in the past. To our knowledge, this is the first reported case of a solid-organ recipient.A 53-year-old woman who underwent a deceased-donor renal transplantation 5 years previously presented with a 12-month history of a giant ulcerated lesion on her left breast. Biopsy of the overlying skin suggested primary angiosarcoma. Concurrently, the patient's bleeding from the site of the biopsy and hematology investigations indicated the presence of Kasabach-Merritt syndrome.The case was discussed in a multidisciplinary setting. The decision was to use anthracycline-based chemotherapy as up-front treatment to assess tumor response and gain a local benefit for a subsequent resection. After the completion of 1 cycle of chemotherapy, the patient died of cardiovascular insufficiency. Primary angiosarcoma of the breast occurs in the third to fourth decade and has been reported only in women.A high clinical suspicion and referral to a specialized center are necessary. Total mastectomy appears to be the only treatment conferring benefit; chemotherapy and radiation therapy are of little value.

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Published In

Transplantation proceedings

DOI

EISSN

1873-2623

ISSN

0041-1345

Publication Date

October 2015

Volume

47

Issue

8

Start / End Page

2537 / 2540

Related Subject Headings

  • Middle Aged
  • Kidney Transplantation
  • Kasabach-Merritt Syndrome
  • Humans
  • Hemangiosarcoma
  • Female
  • Fatal Outcome
  • Breast Neoplasms
  • Biopsy
  • Antineoplastic Agents
 

Citation

APA
Chicago
ICMJE
MLA
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Vailas, M. G., Vernadakis, S., Moris, D., & Zavos, G. (2015). Surgical Dead End in a Renal Transplant Recipient Associated With a Rare Thrombohemorrhagic Syndrome. Transplantation Proceedings, 47(8), 2537–2540. https://doi.org/10.1016/j.transproceed.2015.09.021
Vailas, M. G., S. Vernadakis, D. Moris, and G. Zavos. “Surgical Dead End in a Renal Transplant Recipient Associated With a Rare Thrombohemorrhagic Syndrome.Transplantation Proceedings 47, no. 8 (October 2015): 2537–40. https://doi.org/10.1016/j.transproceed.2015.09.021.
Vailas MG, Vernadakis S, Moris D, Zavos G. Surgical Dead End in a Renal Transplant Recipient Associated With a Rare Thrombohemorrhagic Syndrome. Transplantation proceedings. 2015 Oct;47(8):2537–40.
Vailas, M. G., et al. “Surgical Dead End in a Renal Transplant Recipient Associated With a Rare Thrombohemorrhagic Syndrome.Transplantation Proceedings, vol. 47, no. 8, Oct. 2015, pp. 2537–40. Epmc, doi:10.1016/j.transproceed.2015.09.021.
Vailas MG, Vernadakis S, Moris D, Zavos G. Surgical Dead End in a Renal Transplant Recipient Associated With a Rare Thrombohemorrhagic Syndrome. Transplantation proceedings. 2015 Oct;47(8):2537–2540.
Journal cover image

Published In

Transplantation proceedings

DOI

EISSN

1873-2623

ISSN

0041-1345

Publication Date

October 2015

Volume

47

Issue

8

Start / End Page

2537 / 2540

Related Subject Headings

  • Middle Aged
  • Kidney Transplantation
  • Kasabach-Merritt Syndrome
  • Humans
  • Hemangiosarcoma
  • Female
  • Fatal Outcome
  • Breast Neoplasms
  • Biopsy
  • Antineoplastic Agents