Challenges in the Surgical Treatment of Retroperitoneal Sarcomas

Published

Journal Article

© 2015, Association of Surgeons of India. The objective of this study is to assess long-term prognosis and patterns of failure in patients with retroperitoneal sarcoma who underwent surgery with curative intent at a single institution. We also provide a thorough review of the literature including several series and widely variable data regarding local and distant failure. During a 25-year period (1988–2013), 45 consecutive patients who underwent surgery for retroperitoneal sarcoma at a single referral center were reviewed retrospectively. We recorded and analyzed the presenting symptoms, type of surgical excision, and the 5-year survival rate as well as the local recurrence rate of patients with complete tumor resection. Overall survival is significantly diminished in patients in whom resection margins are not adequate. In our series, 5-year recurrence rate for patients with complete and incomplete resection of the tumor was 30.76 and 68.42 %, respectively. The 5-year survival rate was 51.12 %, and the 5-year survival rate according to type of resection was 76.93 % for complete and 15.79 % for incomplete resections. Local recurrence after first surgery and high-grade malignancy are associated with poor survival. The role of radiation therapy and chemotherapy in the treatment of retroperitoneal sarcoma (RPS) should be investigated further. Complete en bloc resection of the tumor mass and adjacent structures is the single most important factor that improves survival.

Full Text

Duke Authors

Cited Authors

  • Konofaos, P; Spartalis, E; Moris, D; Athanasiou, A; Dimitroulis, D; Markakis, C; Kostakis, ID; Nikiteas, N; Kouraklis, G

Published Date

  • February 1, 2016

Published In

Volume / Issue

  • 78 / 1

Electronic International Standard Serial Number (EISSN)

  • 0973-9793

International Standard Serial Number (ISSN)

  • 0972-2068

Digital Object Identifier (DOI)

  • 10.1007/s12262-015-1292-x

Citation Source

  • Scopus