FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system?

Published

Journal Article (Review)

The focal adhesion kinase (FAK) and the Src families of kinases are subfamilies of the non-receptor protein tyrosine kinases. FAK activity is regulated by gene amplification, alternative splicing and phosporylation/dephosphorylation. FAK/Src complex has been found to participate through various pathways in neuronal models of ischemia-reperfusion injury (IRI) with conflicting results. The aim of the present review is to summarize the currently available data on this subject.The MEDLINE/PubMed database was searched for publications with the medical subject heading IRI and FAK and/or Src, nervous system. We restricted our search till 2014. We identified 93 articles that were available in English as abstracts or/and full-text articles that were deemed appropriate for our review.FAK has been found to have a beneficial preconditioning effect on IRI through activation via the protein kinase C (PKC) pathway by anesthetic agents. Of great importance are the interactions between FAK/Src and VEGF that has been already detected as a protective mean for IRI. The effect of VEGF administration might depend on dose as well as on time of administration. A Ca(2+)/calmodulin-dependent protein kinase II or PKC inhibitors seem to have protective effects on IRI by inhibiting ion channels activation.

Full Text

Duke Authors

Cited Authors

  • Bikis, C; Moris, D; Vasileiou, I; Patsouris, E; Theocharis, S

Published Date

  • April 2015

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 539 - 549

PubMed ID

  • 25474489

Pubmed Central ID

  • 25474489

Electronic International Standard Serial Number (EISSN)

  • 1744-7631

International Standard Serial Number (ISSN)

  • 1472-8222

Digital Object Identifier (DOI)

  • 10.1517/14728222.2014.990374

Language

  • eng