FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system?

Journal Article (Review;Journal Article)


The focal adhesion kinase (FAK) and the Src families of kinases are subfamilies of the non-receptor protein tyrosine kinases. FAK activity is regulated by gene amplification, alternative splicing and phosporylation/dephosphorylation. FAK/Src complex has been found to participate through various pathways in neuronal models of ischemia-reperfusion injury (IRI) with conflicting results. The aim of the present review is to summarize the currently available data on this subject.

Areas covered

The MEDLINE/PubMed database was searched for publications with the medical subject heading IRI and FAK and/or Src, nervous system. We restricted our search till 2014. We identified 93 articles that were available in English as abstracts or/and full-text articles that were deemed appropriate for our review.

Expert opinion

FAK has been found to have a beneficial preconditioning effect on IRI through activation via the protein kinase C (PKC) pathway by anesthetic agents. Of great importance are the interactions between FAK/Src and VEGF that has been already detected as a protective mean for IRI. The effect of VEGF administration might depend on dose as well as on time of administration. A Ca(2+)/calmodulin-dependent protein kinase II or PKC inhibitors seem to have protective effects on IRI by inhibiting ion channels activation.

Full Text

Duke Authors

Cited Authors

  • Bikis, C; Moris, D; Vasileiou, I; Patsouris, E; Theocharis, S

Published Date

  • April 2015

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 539 - 549

PubMed ID

  • 25474489

Electronic International Standard Serial Number (EISSN)

  • 1744-7631

International Standard Serial Number (ISSN)

  • 1472-8222

Digital Object Identifier (DOI)

  • 10.1517/14728222.2014.990374


  • eng