Novel biomarkers of abdominal aortic aneurysm disease: identifying gaps and dispelling misperceptions.

Journal Article (Review;Journal Article)

Abdominal aortic aneurysm (AAA) is a prevalent and potentially life-threatening disease. Early detection by screening programs and subsequent surveillance has been shown to be effective at reducing the risk of mortality due to aneurysm rupture. The aim of this review is to summarize the developments in the literature concerning the latest biomarkers (from 2008 to date) and their potential screening and therapeutic values. Our search included human studies in English and found numerous novel biomarkers under research, which were categorized in 6 groups. Most of these studies are either experimental or hampered by their low numbers of patients. We concluded that currently no specific laboratory markers allow screeing for the disease and monitoring its progression or the results of treatment. Further studies and studies in larger patient groups are required in order to validate biomarkers as cost-effective tools in the AAA disease.

Full Text

Duke Authors

Cited Authors

  • Moris, D; Mantonakis, E; Avgerinos, E; Makris, M; Bakoyiannis, C; Pikoulis, E; Georgopoulos, S

Published Date

  • January 2014

Published In

Volume / Issue

  • 2014 /

Start / End Page

  • 925840 -

PubMed ID

  • 24967416

Pubmed Central ID

  • PMC4055358

Electronic International Standard Serial Number (EISSN)

  • 2314-6141

International Standard Serial Number (ISSN)

  • 2314-6133

Digital Object Identifier (DOI)

  • 10.1155/2014/925840


  • eng