Impact of donor and recipient age difference on long-term allograft survival after living donor renal transplantation: analysis of 478 cases.

Journal Article (Journal Article)

Introduction

Either deceased or living-related renal transplantation constitutes the best therapeutic option for patients with end-stage renal disease. In this retrospective study, an attempt to identify parameters that affect allograft survival in living donor renal transplantation was made.

Methods

Between January 2000 and July 2012, 478 adult patients received a renal transplant from a living-related donor in our center and their records were retrospectively reviewed in November 2012. Data concerning donor age, recipient age, donor/recipient age difference, donor/recipient gender, and ABO compatibility/incompatibility were recorded and associated with renal allograft survival rate.

Results

Renal allograft survival rate was 96%, 89.5%, and 77.7% in the first, fifth, and 10th yr after transplantation, respectively. Only the difference between donor and recipient age was statistically significant in relation to graft survival. In cases with age difference >13 yr, graft survival rate was lower from the third yr onward.

Conclusions

Only the age difference between donor and recipient exerts an adverse impact on graft outcome after living donor renal transplantation, whereas donor age, recipient age, donor/recipient gender, and ABO incompatibility do not significantly influence renal allograft survival.

Full Text

Duke Authors

Cited Authors

  • Kostakis, ID; Moris, DN; Barlas, A; Bokos, I; Darema, M; Theodoropoulou, E; Karaolanis, G; Kostakis, A; Boletis, I; Zavos, G

Published Date

  • November 2013

Published In

Volume / Issue

  • 27 / 6

Start / End Page

  • 838 - 843

PubMed ID

  • 23991890

Electronic International Standard Serial Number (EISSN)

  • 1399-0012

International Standard Serial Number (ISSN)

  • 0902-0063

Digital Object Identifier (DOI)

  • 10.1111/ctr.12219

Language

  • eng