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Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms.

Publication ,  Journal Article
Berger, M; Terrando, N; Smith, SK; Browndyke, JN; Newman, MF; Mathew, JP
Published in: Anesthesiology
October 2018

For half a century, it has been known that some patients experience neurocognitive dysfunction after cardiac surgery; however, defining its incidence, course, and causes remains challenging and controversial. Various terms have been used to describe neurocognitive dysfunction at different times after cardiac surgery, ranging from "postoperative delirium" to "postoperative cognitive dysfunction or decline." Delirium is a clinical diagnosis included in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Postoperative cognitive dysfunction is not included in the DSM-5 and has been heterogeneously defined, though a recent international nomenclature effort has proposed standardized definitions for it. Here, the authors discuss pathophysiologic mechanisms that may underlie these complications, review the literature on methods to prevent them, and discuss novel approaches to understand their etiology that may lead to novel treatment strategies. Future studies should measure both delirium and postoperative cognitive dysfunction to help clarify the relationship between these important postoperative complications.

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Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

October 2018

Volume

129

Issue

4

Start / End Page

829 / 851

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Phenotype
  • Neuropsychological Tests
  • Mental Status and Dementia Tests
  • Humans
  • Cognitive Dysfunction
  • Cardiac Surgical Procedures
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
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Berger, M., Terrando, N., Smith, S. K., Browndyke, J. N., Newman, M. F., & Mathew, J. P. (2018). Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms. Anesthesiology, 129(4), 829–851. https://doi.org/10.1097/ALN.0000000000002194
Berger, Miles, Niccolò Terrando, S Kendall Smith, Jeffrey N. Browndyke, Mark F. Newman, and Joseph P. Mathew. “Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms.Anesthesiology 129, no. 4 (October 2018): 829–51. https://doi.org/10.1097/ALN.0000000000002194.
Berger M, Terrando N, Smith SK, Browndyke JN, Newman MF, Mathew JP. Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms. Anesthesiology. 2018 Oct;129(4):829–51.
Berger, Miles, et al. “Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms.Anesthesiology, vol. 129, no. 4, Oct. 2018, pp. 829–51. Pubmed, doi:10.1097/ALN.0000000000002194.
Berger M, Terrando N, Smith SK, Browndyke JN, Newman MF, Mathew JP. Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms. Anesthesiology. 2018 Oct;129(4):829–851.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

October 2018

Volume

129

Issue

4

Start / End Page

829 / 851

Location

United States

Related Subject Headings

  • Postoperative Complications
  • Phenotype
  • Neuropsychological Tests
  • Mental Status and Dementia Tests
  • Humans
  • Cognitive Dysfunction
  • Cardiac Surgical Procedures
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences