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Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Publication ,  Conference
Berti, A; Warner, R; Johnson, K; Cornec, D; Schroeder, D; Kabat, B; Langford, CA; Hoffman, GS; Fervenza, FC; Kallenberg, CGM; Seo, P ...
Published in: Arthritis Rheumatol
July 2018

OBJECTIVE: To evaluate circulating cytokine profiles in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), classified by antineutrophil cytoplasmic antibody (ANCA) specificity (proteinase 3 ANCA [PR3-ANCA] versus myeloperoxidase ANCA [MPO-ANCA]) or by clinical diagnosis (granulomatosis with polyangiitis [GPA] versus microscopic polyangiitis [MPA]). METHODS: A panel of 29 cytokines was tested in 186 patients with active AAV at inclusion into the Rituximab in AAV trial. Cytokine concentrations were compared between groups within each classification system. Multivariable analyses adjusted for age, sex, and renal insufficiency were performed, with each biomarker as a dependent variable and ANCA specificity and clinical diagnosis as explanatory variables of interest. RESULTS: Levels of 9 circulating cytokines (interleukin-6 [IL-6], granulocyte-macrophage colony-stimulating factor [GM-CSF], IL-15, IL-18, CXCL8/IL-8, CCL-17/thymus and activation-regulated chemokine [TARC], IL-18 binding protein [IL-18 BP], soluble IL-2 receptor α [sIL-2Rα], and nerve growth factor β [NGFβ]) were significantly higher in PR3-AAV than MPO-AAV, 4 cytokines (sIL6R, soluble tumor necrosis factor receptor type II [sTNFRII], neutrophil gelatinase-associated lipocalin [NGAL], and soluble intercellular adhesion molecule 1 [sICAM-1]) were higher in MPO-AAV than in PR3-AAV, 6 cytokines (IL-6, GM-CSF, IL-15, IL-18, sIL-2Rα, and NGFβ) were higher in GPA than in MPA, and 3 cytokines (osteopontin, sTNFRII, and NGAL) were higher in MPA than in GPA (all P < 0.05). For nearly all cytokines, the difference between PR3-AAV and MPO-AAV was larger than that between GPA and MPA. The multivariate analysis showed that 8 cytokines (IL-15, IL-8, IL-18 BP, NGF-β, sICAM-1, TARC, osteopontin, and kidney injury molecule 1 (P < 0.05) distinguished patients with AAV better (lower P values and larger effect sizes) when grouped by ANCA specificity than by clinical diagnosis. CONCLUSION: Distinct cytokine profiles were identified for PR3-AAV versus MPO-AAV and for GPA versus MPA. Differences in these circulating immune mediators are more strongly associated with ANCA specificity than with clinical diagnosis, suggesting that heterogeneity in the AAV subtypes extends beyond clinical phenotypes.

Duke Scholars

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Published In

Arthritis Rheumatol

DOI

EISSN

2326-5205

Publication Date

July 2018

Volume

70

Issue

7

Start / End Page

1114 / 1121

Location

United States

Related Subject Headings

  • Young Adult
  • Sensitivity and Specificity
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Peroxidase
  • Myeloblastin
  • Middle Aged
  • Microscopic Polyangiitis
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Berti, A., Warner, R., Johnson, K., Cornec, D., Schroeder, D., Kabat, B., … RAVE-ITN Research Group, . (2018). Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. In Arthritis Rheumatol (Vol. 70, pp. 1114–1121). United States. https://doi.org/10.1002/art.40471
Berti, Alvise, Roscoe Warner, Kent Johnson, Divi Cornec, Darrell Schroeder, Brian Kabat, Carol A. Langford, et al. “Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.” In Arthritis Rheumatol, 70:1114–21, 2018. https://doi.org/10.1002/art.40471.
Berti A, Warner R, Johnson K, Cornec D, Schroeder D, Kabat B, et al. Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. In: Arthritis Rheumatol. 2018. p. 1114–21.
Berti, Alvise, et al. “Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.Arthritis Rheumatol, vol. 70, no. 7, 2018, pp. 1114–21. Pubmed, doi:10.1002/art.40471.
Berti A, Warner R, Johnson K, Cornec D, Schroeder D, Kabat B, Langford CA, Hoffman GS, Fervenza FC, Kallenberg CGM, Seo P, Spiera R, St Clair EW, Brunetta P, Stone JH, Merkel PA, Specks U, Monach PA, RAVE-ITN Research Group. Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol. 2018. p. 1114–1121.
Journal cover image

Published In

Arthritis Rheumatol

DOI

EISSN

2326-5205

Publication Date

July 2018

Volume

70

Issue

7

Start / End Page

1114 / 1121

Location

United States

Related Subject Headings

  • Young Adult
  • Sensitivity and Specificity
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Peroxidase
  • Myeloblastin
  • Middle Aged
  • Microscopic Polyangiitis
  • Male
  • Humans