Assessment Tools for Peripheral Neuropathy in Pediatric Oncology: A Systematic Review From the Children's Oncology Group.


Journal Article

Peripheral neuropathy is a known side effect of several chemotherapy agents, including vinca alkaloids and platinum-based chemotherapy. Early recognition and monitoring of this side effect is an important role of the pediatric oncology nurse. There are a variety of peripheral neuropathy assessment tools currently in use, but the usefulness of these tools in identifying and grading neuropathy in children varies, and there is currently no standardized tool in place to evaluate peripheral neuropathy in pediatric oncology. A systematic review was performed to identify the peripheral neuropathy assessment tools that best evaluate the early onset and progression of peripheral neuropathy in pediatric patients receiving vincristine. Because of the limited information available in pediatric oncology, this review was extended to any pediatric patient with neuropathy. A total of 8 studies were included in the evidence synthesis. Based on available evidence, the pediatric-modified Total Neuropathy Scale (ped-m TNS) and the Total Neuropathy Score-pediatric version (TNS-PV) are recommended for the assessment of vincristine-induced peripheral neuropathy in children 6 years of age and older. In addition, several studies demonstrated that subjective symptoms alone are not adequate to assess for vincristine-induced peripheral neuropathy. Nursing assessment of peripheral neuropathy should be an integral and regular part of patient care throughout the course of chemotherapy treatment.

Full Text

Cited Authors

  • Smolik, S; Arland, L; Hensley, MA; Schissel, D; Shepperd, B; Thomas, K; Rodgers, C

Published Date

  • July 2018

Published In

Volume / Issue

  • 35 / 4

Start / End Page

  • 267 - 275

PubMed ID

  • 29566596

Pubmed Central ID

  • 29566596

Electronic International Standard Serial Number (EISSN)

  • 1532-8457

International Standard Serial Number (ISSN)

  • 1043-4542

Digital Object Identifier (DOI)

  • 10.1177/1043454218762705


  • eng