Skip to main content
Journal cover image

Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.

Publication ,  Journal Article
Tambur, AR; Campbell, P; Claas, FH; Feng, S; Gebel, HM; Jackson, AM; Mannon, RB; Reed, EF; Tinckam, K; Askar, M; Chandraker, A; Chang, PP ...
Published in: Am J Transplant
July 2018

The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced significantly in recent years, the criteria to define presence of a DSA and assign a level of risk for a given DSA vary markedly between centers. A collaborative effort between the American Society for Histocompatibility and Immunogenetics and the American Society of Transplantation provided the logistical support for generating a dedicated multidisciplinary working group, which included experts in histocompatibility as well as kidney, liver, heart, and lung transplantation. The goals were to perform a critical review of biologically driven, state-of-the-art, clinical diagnostics literature and to provide clinical practice recommendations based on expert assessment of quality and strength of evidence. The results of the Sensitization in Transplantation: Assessment of Risk (STAR) meeting are summarized here, providing recommendations on the definition and utilization of HLA diagnostic testing, and a framework for clinical assessment of risk for a memory or a primary alloimmune response. The definitions, recommendations, risk framework, and highlighted gaps in knowledge are intended to spur research that will inform the next STAR Working Group meeting in 2019.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

July 2018

Volume

18

Issue

7

Start / End Page

1604 / 1614

Location

United States

Related Subject Headings

  • Tissue Donors
  • Surgery
  • Risk Assessment
  • Research Report
  • Practice Guidelines as Topic
  • Organ Transplantation
  • Isoantibodies
  • Humans
  • Histocompatibility
  • HLA Antigens
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tambur, A. R., Campbell, P., Claas, F. H., Feng, S., Gebel, H. M., Jackson, A. M., … Nickerson, P. (2018). Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report. Am J Transplant, 18(7), 1604–1614. https://doi.org/10.1111/ajt.14752
Tambur, Anat R., Patricia Campbell, Frans H. Claas, Sandy Feng, Howard M. Gebel, Annette M. Jackson, Roslyn B. Mannon, et al. “Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.Am J Transplant 18, no. 7 (July 2018): 1604–14. https://doi.org/10.1111/ajt.14752.
Tambur AR, Campbell P, Claas FH, Feng S, Gebel HM, Jackson AM, et al. Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report. Am J Transplant. 2018 Jul;18(7):1604–14.
Tambur, Anat R., et al. “Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.Am J Transplant, vol. 18, no. 7, July 2018, pp. 1604–14. Pubmed, doi:10.1111/ajt.14752.
Tambur AR, Campbell P, Claas FH, Feng S, Gebel HM, Jackson AM, Mannon RB, Reed EF, Tinckam K, Askar M, Chandraker A, Chang PP, Colvin M, Demetris A-J, Diamond JM, Dipchand AI, Fairchild RL, Ford ML, Friedewald J, Gill RG, Glotz D, Goldberg H, Hachem R, Knechtle S, Kobashigawa J, Levine DJ, Levitsky J, Mengel M, Milford E, Newell KA, O’Leary JG, Palmer S, Randhawa P, Smith J, Snyder L, Starling RC, Sweet S, Taner T, Taylor CJ, Woodle S, Zeevi A, Nickerson P. Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report. Am J Transplant. 2018 Jul;18(7):1604–1614.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

July 2018

Volume

18

Issue

7

Start / End Page

1604 / 1614

Location

United States

Related Subject Headings

  • Tissue Donors
  • Surgery
  • Risk Assessment
  • Research Report
  • Practice Guidelines as Topic
  • Organ Transplantation
  • Isoantibodies
  • Humans
  • Histocompatibility
  • HLA Antigens