Pleomorphic adenoma of the lacrimal gland: A review with updates on malignant transformation and molecular genetics

Journal Article (Review;Journal)

Pleomorphic adenoma (benign mixed tumor) is the most common epithelial neoplasm of the lacrimal gland. It is usually a slow growing, well-circumscribed, mass that is identical to its salivary gland counterpart. Patients generally have an excellent prognosis for vision and long-term survival after complete surgical excision. There is a tendency to reoccur, especially if there is an incomplete excision, and rarely, malignant transformation to carcinoma ex pleomorphic adenoma can occur, which has a much poorer prognosis. The molecular genetics of lacrimal gland pleomorphic adenomas have only recently been studies, but appear to display similar genetic aberration found in the salivary gland counterparts.

Full Text

Duke Authors

Cited Authors

  • Harrison, W; Pittman, P; Cummings, T

Published Date

  • January 1, 2018

Published In

Volume / Issue

  • 32 / 1

Start / End Page

  • 13 - 16

International Standard Serial Number (ISSN)

  • 1319-4534

Digital Object Identifier (DOI)

  • 10.1016/j.sjopt.2018.02.014

Citation Source

  • Scopus