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The Selective Use of Radiation Therapy in Rectal Cancer Patients.

Publication ,  Journal Article
Martella, A; Willett, C; Palta, M; Czito, B
Published in: Curr Oncol Rep
April 11, 2018

PURPOSE OF REVIEW: Colorectal cancer has a high global incidence, and standard treatment employs a multimodality approach. In addition to cure, minimizing treatment-related toxicity and improving the therapeutic ratio is a common goal. The following article addresses the potential of omitting radiotherapy in select rectal cancer patients. RECENT FINDINGS: Omission of radiotherapy in rectal cancer is analyzed in the context of historical findings, as well as more recent data describing risk stratification of stage II-III disease, surgical optimization, imaging limitations, improvement in systemic chemotherapeutic agents, and contemporary studies evaluating selective omission of radiotherapy. A subset of rectal cancer patients exists that may be considered low to intermediate risk for locoregional recurrence. With appropriate staging, surgical technique, and possibly improved systemic therapy, it may be feasible to selectively omit radiotherapy in these patients. Current imaging limitations as well as evidence of increased locoregional recurrence following radiotherapy omission lend us to continue supporting the standard treatment of approach of neoadjuvant chemoradiation therapy followed by surgical resection until additional improvements and prospective evidence can support otherwise.

Duke Scholars

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

April 11, 2018

Volume

20

Issue

6

Start / End Page

43

Location

United States

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Humans
  • Fluorouracil
  • Combined Modality Therapy
  • Chemoradiotherapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Martella, A., Willett, C., Palta, M., & Czito, B. (2018). The Selective Use of Radiation Therapy in Rectal Cancer Patients. Curr Oncol Rep, 20(6), 43. https://doi.org/10.1007/s11912-018-0689-7
Martella, Andrew, Christopher Willett, Manisha Palta, and Brian Czito. “The Selective Use of Radiation Therapy in Rectal Cancer Patients.Curr Oncol Rep 20, no. 6 (April 11, 2018): 43. https://doi.org/10.1007/s11912-018-0689-7.
Martella A, Willett C, Palta M, Czito B. The Selective Use of Radiation Therapy in Rectal Cancer Patients. Curr Oncol Rep. 2018 Apr 11;20(6):43.
Martella, Andrew, et al. “The Selective Use of Radiation Therapy in Rectal Cancer Patients.Curr Oncol Rep, vol. 20, no. 6, Apr. 2018, p. 43. Pubmed, doi:10.1007/s11912-018-0689-7.
Martella A, Willett C, Palta M, Czito B. The Selective Use of Radiation Therapy in Rectal Cancer Patients. Curr Oncol Rep. 2018 Apr 11;20(6):43.
Journal cover image

Published In

Curr Oncol Rep

DOI

EISSN

1534-6269

Publication Date

April 11, 2018

Volume

20

Issue

6

Start / End Page

43

Location

United States

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Humans
  • Fluorouracil
  • Combined Modality Therapy
  • Chemoradiotherapy
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis