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Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.

Publication ,  Journal Article
Yan, W; Wu, X; Zhou, W; Fong, MY; Cao, M; Liu, J; Liu, X; Chen, C-H; Fadare, O; Pizzo, DP; Wu, J; Liu, L; Liu, X; Chin, AR; Ren, X ...
Published in: Nat Cell Biol
May 2018

Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-cancer-secreted, extracellular-vesicle-encapsulated miR-105, which is induced by the oncoprotein MYC in cancer cells and, in turn, activates MYC signalling in cancer-associated fibroblasts (CAFs) to induce a metabolic program. This results in the capacity of CAFs to display different metabolic features in response to changes in the metabolic environment. When nutrients are sufficient, miR-105-reprogrammed CAFs enhance glucose and glutamine metabolism to fuel adjacent cancer cells. When nutrient levels are low and metabolic by-products accumulate, these CAFs detoxify metabolic wastes, including lactic acid and ammonium, by converting them into energy-rich metabolites. Thus, the miR-105-mediated metabolic reprogramming of stromal cells contributes to sustained tumour growth by conditioning the shared metabolic environment.

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Published In

Nat Cell Biol

DOI

EISSN

1476-4679

Publication Date

May 2018

Volume

20

Issue

5

Start / End Page

597 / 609

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Tumor Cells, Cultured
  • Tumor Burden
  • Time Factors
  • Stromal Cells
  • Signal Transduction
  • Proto-Oncogene Proteins c-myc
  • Paracrine Communication
  • NIH 3T3 Cells
  • MicroRNAs
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yan, W., Wu, X., Zhou, W., Fong, M. Y., Cao, M., Liu, J., … Wang, S. E. (2018). Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol, 20(5), 597–609. https://doi.org/10.1038/s41556-018-0083-6
Yan, Wei, Xiwei Wu, Weiying Zhou, Miranda Y. Fong, Minghui Cao, Juan Liu, Xiaojing Liu, et al. “Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.Nat Cell Biol 20, no. 5 (May 2018): 597–609. https://doi.org/10.1038/s41556-018-0083-6.
Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, et al. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018 May;20(5):597–609.
Yan, Wei, et al. “Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.Nat Cell Biol, vol. 20, no. 5, May 2018, pp. 597–609. Pubmed, doi:10.1038/s41556-018-0083-6.
Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen C-H, Fadare O, Pizzo DP, Wu J, Liu L, Chin AR, Ren X, Chen Y, Locasale JW, Wang SE. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018 May;20(5):597–609.

Published In

Nat Cell Biol

DOI

EISSN

1476-4679

Publication Date

May 2018

Volume

20

Issue

5

Start / End Page

597 / 609

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Tumor Cells, Cultured
  • Tumor Burden
  • Time Factors
  • Stromal Cells
  • Signal Transduction
  • Proto-Oncogene Proteins c-myc
  • Paracrine Communication
  • NIH 3T3 Cells
  • MicroRNAs