Cognitive effects of transcranial direct current stimulation treatment in patients with major depressive disorder: An individual patient data meta-analysis of randomised, sham-controlled trials.


Journal Article (Review)

Transcranial direct current stimulation (tDCS) has emerged as a promising new treatment for major depression. While recent randomised, sham-controlled studies found tDCS to have antidepressant effects, it remains to be determined whether a tDCS treatment course may also enhance cognitive function independent of mood effects in depressed patients. This systematic review and individual patient data (IPD) meta-analysis examined cognitive outcomes from randomised, sham-controlled trials of tDCS treatment for major depression. Seven randomised, sham-controlled trials (n = 478 participants, 260 in active and 218 in sham) of tDCS for major depression were included. Results showed no cognitive enhancement after active tDCS compared to sham for the 12 cognitive outcomes investigated. Active relative to sham tDCS treatment was associated with reduced performance gains on a measure of processing speed (β = -0.33, 95% CI -0.58; -0.08, p = 0.011). Active tDCS treatment for depression did not show cognitive benefits independent of mood effects. Rather, tDCS treatment relative to sham stimulation for major depression may instead be associated with a reduced practice effect for processing speed.

Full Text

Duke Authors

Cited Authors

  • Martin, DM; Moffa, A; Nikolin, S; Bennabi, D; Brunoni, AR; Flannery, W; Haffen, E; McClintock, SM; Moreno, ML; Padberg, F; Palm, U; Loo, CK

Published Date

  • July 2018

Published In

Volume / Issue

  • 90 /

Start / End Page

  • 137 - 145

PubMed ID

  • 29660416

Pubmed Central ID

  • 29660416

Electronic International Standard Serial Number (EISSN)

  • 1873-7528

Digital Object Identifier (DOI)

  • 10.1016/j.neubiorev.2018.04.008


  • eng

Conference Location

  • United States