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In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.

Publication ,  Journal Article
Khodabukus, A; Prabhu, N; Wang, J; Bursac, N
Published in: Advanced healthcare materials
August 2018

Healthy skeletal muscle possesses the extraordinary ability to regenerate in response to small-scale injuries; however, this self-repair capacity becomes overwhelmed with aging, genetic myopathies, and large muscle loss. The failure of small animal models to accurately replicate human muscle disease, injury and to predict clinically-relevant drug responses has driven the development of high fidelity in vitro skeletal muscle models. Herein, the progress made and challenges ahead in engineering biomimetic human skeletal muscle tissues that can recapitulate muscle development, genetic diseases, regeneration, and drug response is discussed. Bioengineering approaches used to improve engineered muscle structure and function as well as the functionality of satellite cells to allow modeling muscle regeneration in vitro are also highlighted. Next, a historical overview on the generation of skeletal muscle cells and tissues from human pluripotent stem cells, and a discussion on the potential of these approaches to model and treat genetic diseases such as Duchenne muscular dystrophy, is provided. Finally, the need to integrate multiorgan microphysiological systems to generate improved drug discovery technologies with the potential to complement or supersede current preclinical animal models of muscle disease is described.

Duke Scholars

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Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

August 2018

Volume

7

Issue

15

Start / End Page

e1701498

Related Subject Headings

  • Tissue Engineering
  • Satellite Cells, Skeletal Muscle
  • Pluripotent Stem Cells
  • Muscle, Skeletal
  • Humans
  • Bioengineering
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology
 

Citation

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ICMJE
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Khodabukus, A., Prabhu, N., Wang, J., & Bursac, N. (2018). In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. Advanced Healthcare Materials, 7(15), e1701498. https://doi.org/10.1002/adhm.201701498
Khodabukus, Alastair, Neel Prabhu, Jason Wang, and Nenad Bursac. “In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.Advanced Healthcare Materials 7, no. 15 (August 2018): e1701498. https://doi.org/10.1002/adhm.201701498.
Khodabukus A, Prabhu N, Wang J, Bursac N. In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. Advanced healthcare materials. 2018 Aug;7(15):e1701498.
Khodabukus, Alastair, et al. “In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.Advanced Healthcare Materials, vol. 7, no. 15, Aug. 2018, p. e1701498. Epmc, doi:10.1002/adhm.201701498.
Khodabukus A, Prabhu N, Wang J, Bursac N. In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. Advanced healthcare materials. 2018 Aug;7(15):e1701498.
Journal cover image

Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

August 2018

Volume

7

Issue

15

Start / End Page

e1701498

Related Subject Headings

  • Tissue Engineering
  • Satellite Cells, Skeletal Muscle
  • Pluripotent Stem Cells
  • Muscle, Skeletal
  • Humans
  • Bioengineering
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 1004 Medical Biotechnology