Skip to main content

Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma.

Publication ,  Journal Article
Kumar, A; Smith, CEP; Giorgi, EE; Eudailey, J; Martinez, DR; Yusim, K; Douglas, AO; Stamper, L; McGuire, E; LaBranche, CC; Montefiori, DC ...
Published in: PLoS Pathog
April 2018

Despite extensive genetic diversity of HIV-1 in chronic infection, a single or few maternal virus variants become the founders of an infant's infection. These transmitted/founder (T/F) variants are of particular interest, as a maternal or infant HIV vaccine should raise envelope (Env) specific IgG responses capable of blocking this group of viruses. However, the maternal or infant factors that contribute to selection of infant T/F viruses are not well understood. In this study, we amplified HIV-1 env genes by single genome amplification from 16 mother-infant transmitting pairs from the U.S. pre-antiretroviral era Women Infant Transmission Study (WITS). Infant T/F and representative maternal non-transmitted Env variants from plasma were identified and used to generate pseudoviruses for paired maternal plasma neutralization sensitivity analysis. Eighteen out of 21 (85%) infant T/F Env pseudoviruses were neutralization resistant to paired maternal plasma. Yet, all infant T/F viruses were neutralization sensitive to a panel of HIV-1 broadly neutralizing antibodies and variably sensitive to heterologous plasma neutralizing antibodies. Also, these infant T/F pseudoviruses were overall more neutralization resistant to paired maternal plasma in comparison to pseudoviruses from maternal non-transmitted variants (p = 0.012). Altogether, our findings suggest that autologous neutralization of circulating viruses by maternal plasma antibodies select for neutralization-resistant viruses that initiate peripartum transmission, raising the speculation that enhancement of this response at the end of pregnancy could further reduce infant HIV-1 infection risk.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS Pathog

DOI

EISSN

1553-7374

Publication Date

April 2018

Volume

14

Issue

4

Start / End Page

e1006944

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virology
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Plasma
  • Peripartum Period
  • Neutralization Tests
  • Infectious Disease Transmission, Vertical
  • Infant
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kumar, A., Smith, C. E. P., Giorgi, E. E., Eudailey, J., Martinez, D. R., Yusim, K., … Permar, S. R. (2018). Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma. PLoS Pathog, 14(4), e1006944. https://doi.org/10.1371/journal.ppat.1006944
Kumar, Amit, Claire E. P. Smith, Elena E. Giorgi, Joshua Eudailey, David R. Martinez, Karina Yusim, Ayooluwa O. Douglas, et al. “Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma.PLoS Pathog 14, no. 4 (April 2018): e1006944. https://doi.org/10.1371/journal.ppat.1006944.
Kumar A, Smith CEP, Giorgi EE, Eudailey J, Martinez DR, Yusim K, et al. Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma. PLoS Pathog. 2018 Apr;14(4):e1006944.
Kumar, Amit, et al. “Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma.PLoS Pathog, vol. 14, no. 4, Apr. 2018, p. e1006944. Pubmed, doi:10.1371/journal.ppat.1006944.
Kumar A, Smith CEP, Giorgi EE, Eudailey J, Martinez DR, Yusim K, Douglas AO, Stamper L, McGuire E, LaBranche CC, Montefiori DC, Fouda GG, Gao F, Permar SR. Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma. PLoS Pathog. 2018 Apr;14(4):e1006944.

Published In

PLoS Pathog

DOI

EISSN

1553-7374

Publication Date

April 2018

Volume

14

Issue

4

Start / End Page

e1006944

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virology
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Plasma
  • Peripartum Period
  • Neutralization Tests
  • Infectious Disease Transmission, Vertical
  • Infant
  • Humans