lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.

Published

Journal Article

We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1,006 lncRNA genes in cancer, including EPIC1 (epigenetically-induced lncRNA1). Overexpression of EPIC1 is associated with poor prognosis in luminal B breast cancer patients and enhances tumor growth in vitro and in vivo. Mechanistically, EPIC1 promotes cell-cycle progression by interacting with MYC through EPIC1's 129-283 nt region. EPIC1 knockdown reduces the occupancy of MYC to its target genes (e.g., CDKN1A, CCNA2, CDC20, and CDC45). MYC depletion abolishes EPIC1's regulation of MYC target and luminal breast cancer tumorigenesis in vitro and in vivo.

Full Text

Duke Authors

Cited Authors

  • Wang, Z; Yang, B; Zhang, M; Guo, W; Wu, Z; Wang, Y; Jia, L; Li, S; Cancer Genome Atlas Research Network, ; Xie, W; Yang, D

Published Date

  • April 9, 2018

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 706 - 720.e9

PubMed ID

  • 29622465

Pubmed Central ID

  • 29622465

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2018.03.006

Language

  • eng

Conference Location

  • United States