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Oncogenic Signaling Pathways in The Cancer Genome Atlas.

Publication ,  Journal Article
Sanchez-Vega, F; Mina, M; Armenia, J; Chatila, WK; Luna, A; La, KC; Dimitriadoy, S; Liu, DL; Kantheti, HS; Saghafinia, S; Chakravarty, D ...
Published in: Cell
April 5, 2018

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 5, 2018

Volume

173

Issue

2

Start / End Page

321 / 337.e10

Location

United States

Related Subject Headings

  • Wnt Proteins
  • Tumor Suppressor Protein p53
  • Transforming Growth Factor beta
  • Signal Transduction
  • Phosphatidylinositol 3-Kinases
  • Neoplasms
  • Humans
  • Genes, Neoplasm
  • Developmental Biology
  • Databases, Genetic
 

Citation

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ICMJE
MLA
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Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., … Schultz, N. (2018). Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell, 173(2), 321-337.e10. https://doi.org/10.1016/j.cell.2018.03.035
Sanchez-Vega, Francisco, Marco Mina, Joshua Armenia, Walid K. Chatila, Augustin Luna, Konnor C. La, Sofia Dimitriadoy, et al. “Oncogenic Signaling Pathways in The Cancer Genome Atlas.Cell 173, no. 2 (April 5, 2018): 321-337.e10. https://doi.org/10.1016/j.cell.2018.03.035.
Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, et al. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 Apr 5;173(2):321-337.e10.
Sanchez-Vega, Francisco, et al. “Oncogenic Signaling Pathways in The Cancer Genome Atlas.Cell, vol. 173, no. 2, Apr. 2018, pp. 321-337.e10. Pubmed, doi:10.1016/j.cell.2018.03.035.
Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang W-W, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 Apr 5;173(2):321-337.e10.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 5, 2018

Volume

173

Issue

2

Start / End Page

321 / 337.e10

Location

United States

Related Subject Headings

  • Wnt Proteins
  • Tumor Suppressor Protein p53
  • Transforming Growth Factor beta
  • Signal Transduction
  • Phosphatidylinositol 3-Kinases
  • Neoplasms
  • Humans
  • Genes, Neoplasm
  • Developmental Biology
  • Databases, Genetic