An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.

Published

Journal Article

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale.

Full Text

Duke Authors

Cited Authors

  • Liu, J; Lichtenberg, T; Hoadley, KA; Poisson, LM; Lazar, AJ; Cherniack, AD; Kovatich, AJ; Benz, CC; Levine, DA; Lee, AV; Omberg, L; Wolf, DM; Shriver, CD; Thorsson, V; Cancer Genome Atlas Research Network, ; Hu, H

Published Date

  • April 2018

Published In

Volume / Issue

  • 173 / 2

Start / End Page

  • 400 - 416.e11

PubMed ID

  • 29625055

Pubmed Central ID

  • 29625055

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2018.02.052

Language

  • eng