Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Published

Journal Article

Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Aneuploidy was anti-correlated with expression of immune signaling genes, due to decreased leukocyte infiltrates in high-aneuploidy samples. Chromosome arm-level alterations show cancer-specific patterns, including loss of chromosome arm 3p in squamous cancers. We applied genome engineering to delete 3p in lung cells, causing decreased proliferation rescued in part by chromosome 3 duplication. This study defines genomic and phenotypic correlates of cancer aneuploidy and provides an experimental approach to study chromosome arm aneuploidy.

Full Text

Duke Authors

Cited Authors

  • Taylor, AM; Shih, J; Ha, G; Gao, GF; Zhang, X; Berger, AC; Schumacher, SE; Wang, C; Hu, H; Liu, J; Lazar, AJ; Cancer Genome Atlas Research Network, ; Cherniack, AD; Beroukhim, R; Meyerson, M

Published Date

  • April 9, 2018

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 676 - 689.e3

PubMed ID

  • 29622463

Pubmed Central ID

  • 29622463

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2018.03.007

Language

  • eng

Conference Location

  • United States