State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.

Journal Article (Journal Article;Systematic Review)

Major depression in older adults, or late-life depression (LLD), is a common and debilitating psychiatric disorder that increases the risk of morbidity and mortality. Although the effects of LLD make it important to achieve a diagnosis and start treatment quickly, individuals with LLD are often inadequately or unsuccessfully treated. The latest treatment developments suggest that interventions targeting executive dysfunction and neuroticism, constructs associated with poor response to antidepressants in older adults, are successful in treating LLD. Specific behavioral interventions (computerized cognitive training, mindfulness meditation, aerobic exercise) appear to decrease depressive symptoms and ameliorate executive dysfunction and neuroticism, but we do not fully understand the mechanisms by which these treatments work. We review recent research on neural network changes underlying executive dysfunction and neuroticism in LLD and their association with clinical outcomes (e.g., treatment response, cognitive functioning).

Full Text

Duke Authors

Cited Authors

  • Manning, KJ; Steffens, DC

Published Date

  • April 2018

Published In

Volume / Issue

  • 66 Suppl 1 / Suppl 1

Start / End Page

  • S17 - S23

PubMed ID

  • 29659005

Pubmed Central ID

  • PMC5905432

Electronic International Standard Serial Number (EISSN)

  • 1532-5415

Digital Object Identifier (DOI)

  • 10.1111/jgs.15353


  • eng

Conference Location

  • United States