Clinicopathologic factors and adjuvant treatment effects on survival in adult head and neck synovial cell sarcoma.


Journal Article

BACKGROUND: Synovial cell sarcoma is a rare soft tissue sarcoma. The purpose of this study was to investigate clinicopathologic factors and management on survival in primary synovial sarcoma of the head and neck. METHODS: We conducted a retrospective case series of medical records. Standard Kaplan-Meier survival analyses and accompanying log-rank tests were used. RESULTS: Twenty-eight patients were identified. All patients had surgery in attempt to remove the primary lesion. Nine patients received adjuvant radiation therapy, 2 received chemotherapy, and 14 received chemoradiation therapy postoperatively. Metastases on initial presentation and tumor size >4 cm decreased survival. No significant effect on overall survival or local tumor recurrence with histologic subtype, lymph node involvement at diagnosis, tumors >5 cm, or when comparing adjuvant therapy types. CONCLUSION: Although surgery remains the mainstay of treatment, our results do not suggest that adding chemotherapy to postoperative radiotherapy confers a survival or control benefit.

Full Text

Duke Authors

Cited Authors

  • Crowson, MG; Lalich, I; Keeney, MG; Garcia, JJ; Price, DL

Published Date

  • March 2015

Published In

Volume / Issue

  • 37 / 3

Start / End Page

  • 375 - 380

PubMed ID

  • 24430934

Pubmed Central ID

  • 24430934

Electronic International Standard Serial Number (EISSN)

  • 1097-0347

Digital Object Identifier (DOI)

  • 10.1002/hed.23605


  • eng

Conference Location

  • United States