Characterization of the airway smooth muscle muscarinic receptor in vivo.

Journal Article (Journal Article)

We examined the bronchodilator activity of eight subtype-selective and non-selective muscarinic antagonists in anesthetized, ventilated guinea pigs bronchoconstricted by carbachol aerosols. Relative bronchodilator potencies were consistent with M3 receptor antagonism and correlated with inhibition of bladder smooth muscle contraction in vivo. We conclude that the airway smooth muscle muscarinic receptor can be functionally characterized in vivo as M3 and that it is of the same subtype as the muscarinic receptor in bladder smooth muscle.

Full Text

Duke Authors

Cited Authors

  • Howell, RE; Laemont, K; Gaudette, R; Raynor, M; Warner, A; Noronha-Blob, L

Published Date

  • May 1991

Published In

Volume / Issue

  • 197 / 1

Start / End Page

  • 109 - 112

PubMed ID

  • 1893919

Electronic International Standard Serial Number (EISSN)

  • 1879-0712

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(91)90372-w

Language

  • eng