A Connectome-wide Functional Signature of Transdiagnostic Risk for Mental Illness.


Journal Article

BACKGROUND:High rates of comorbidity, shared risk, and overlapping therapeutic mechanisms have led psychopathology research toward transdiagnostic dimensional investigations of clustered symptoms. One influential framework accounts for these transdiagnostic phenomena through a single general factor, sometimes referred to as the p factor, associated with risk for all common forms of mental illness. METHODS:We build on previous research identifying unique structural neural correlates of the p factor by conducting a data-driven analysis of connectome-wide intrinsic functional connectivity (n = 605). RESULTS:We demonstrate that higher p factor scores and associated risk for common mental illness maps onto hyperconnectivity between visual association cortex and both frontoparietal and default mode networks. CONCLUSIONS:These results provide initial evidence that the transdiagnostic risk for common forms of mental illness is associated with patterns of inefficient connectome-wide intrinsic connectivity between visual association cortex and networks supporting executive control and self-referential processes, networks that are often impaired across categorical disorders.

Full Text

Duke Authors

Cited Authors

  • Elliott, ML; Romer, A; Knodt, AR; Hariri, AR

Published Date

  • September 2018

Published In

Volume / Issue

  • 84 / 6

Start / End Page

  • 452 - 459

PubMed ID

  • 29779670

Pubmed Central ID

  • 29779670

Electronic International Standard Serial Number (EISSN)

  • 1873-2402

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2018.03.012


  • eng