Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.

Journal Article (Journal Article;Review)

Soft tissue sarcomas (STS) are heterogeneous, mesenchymal malignancies with variable biologic behavior. The primary management for localized STS is surgical resection, which may be combined with neoadjuvant or adjuvant radiation therapy to increase the probability of achieving local control. Many patients with large, high-grade STS develop metastatic disease. Several clinical trials of immune checkpoint blockade for STS have produced promising responses in patients with metastatic disease. In this review, recent and ongoing clinical trials of immune checkpoint inhibition for STS are discussed. The authors explain the rationale for immune checkpoint inhibition and radiation therapy and highlight new studies testing this combination in the neoadjuvant setting for patients with high-risk STS. In addition, they describe novel combinations of immunotherapy with targeted therapies and chemotherapies being tested in the metastatic setting and discuss how these combinations have the potential to be integrated into adjuvant therapy in the future.

Full Text

Duke Authors

Cited Authors

  • Wisdom, AJ; Mowery, YM; Riedel, RF; Kirsch, DG

Published Date

  • October 1, 2018

Published In

Volume / Issue

  • 124 / 19

Start / End Page

  • 3819 - 3829

PubMed ID

  • 29723407

Pubmed Central ID

  • PMC6215523

Electronic International Standard Serial Number (EISSN)

  • 1097-0142

Digital Object Identifier (DOI)

  • 10.1002/cncr.31517


  • eng

Conference Location

  • United States