Executive functioning and central coherence in anorexia nervosa: Pilot investigation of a neurocognitive endophenotype.

Journal Article (Journal Article)

A neurocognitive profile characterized by problems in set shifting, executive functioning, and central coherence may pre-date and maintain anorexia nervosa (AN). To test this pattern as a possible endophenotype for AN, 10 youth with current AN, 14 healthy youth, and their biological parents, participated in a neuropsychological battery. Youth with AN demonstrated significantly weaker central coherence, related to enhanced detail-focused processing. Youth with AN and their parents demonstrated significantly greater psychopathology relative to controls, and youth-parent scores were significantly correlated. The study, limited by a small sample size, found little evidence supporting a neuropsychological endophenotype for AN. Identifying a neurocognitive profile for children and adolescents with AN has important implications for the treatment of young patients.

Full Text

Duke Authors

Cited Authors

  • Brown, M; Loeb, KL; McGrath, RE; Tiersky, L; Zucker, N; Carlin, A

Published Date

  • September 2018

Published In

Volume / Issue

  • 26 / 5

Start / End Page

  • 489 - 498

PubMed ID

  • 29700970

Electronic International Standard Serial Number (EISSN)

  • 1099-0968

Digital Object Identifier (DOI)

  • 10.1002/erv.2597


  • eng

Conference Location

  • England