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Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.

Publication ,  Journal Article
Zuo, X; Luciano, A; Pieper, CF; Bain, JR; Kraus, VB; Kraus, WE; Morey, MC; Cohen, HJ
Published in: J Am Geriatr Soc
July 2018

OBJECTIVES: To determine whether combinations of inflammatory markers are related to physical function. DESIGN AND SUBJECTS: secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data from 3 cohorts of older adults with different health and disease status were employed. Twenty markers of inflammation and metabolism were individually assessed for correlation with usual gait speed and were separated into robust and impairment quartiles. For the robustness and impairment indices, individual markers were selected using step-wise regression over bootstrapping iterations, and regression coefficients were estimated for the markers individually and collectively as an additive score. RESULTS: We developed a robustness index involving 6 markers and an impairment index involving 8 markers corresponding positively and negatively with gait speed. Two markers, glycine and tumor necrosis factor receptor 1 (TNFR1), appeared only in the robustness index, and TNFR2; regulated on activation, normal T-cell expressed and secreted; the amino acid factor; and matrix metallopeptidase 3; appeared only in the impairment index. CONCLUSION: Indices of biomarkers were associated with robust and impaired physical performance but differ, in composition suggesting potential biological differences that may contribute to robustness and impairment.

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Published In

J Am Geriatr Soc

DOI

EISSN

1532-5415

Publication Date

July 2018

Volume

66

Issue

7

Start / End Page

1353 / 1359

Location

United States

Related Subject Headings

  • Physical Fitness
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Health Status Indicators
  • Geriatrics
  • Geriatric Assessment
  • Gait
  • Female
 

Citation

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Zuo, X., Luciano, A., Pieper, C. F., Bain, J. R., Kraus, V. B., Kraus, W. E., … Cohen, H. J. (2018). Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults. J Am Geriatr Soc, 66(7), 1353–1359. https://doi.org/10.1111/jgs.15393
Zuo, Xintong, Alison Luciano, Carl F. Pieper, James R. Bain, Virginia B. Kraus, William E. Kraus, Miriam C. Morey, and Harvey J. Cohen. “Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.J Am Geriatr Soc 66, no. 7 (July 2018): 1353–59. https://doi.org/10.1111/jgs.15393.
Zuo X, Luciano A, Pieper CF, Bain JR, Kraus VB, Kraus WE, et al. Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults. J Am Geriatr Soc. 2018 Jul;66(7):1353–9.
Zuo, Xintong, et al. “Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.J Am Geriatr Soc, vol. 66, no. 7, July 2018, pp. 1353–59. Pubmed, doi:10.1111/jgs.15393.
Zuo X, Luciano A, Pieper CF, Bain JR, Kraus VB, Kraus WE, Morey MC, Cohen HJ. Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults. J Am Geriatr Soc. 2018 Jul;66(7):1353–1359.
Journal cover image

Published In

J Am Geriatr Soc

DOI

EISSN

1532-5415

Publication Date

July 2018

Volume

66

Issue

7

Start / End Page

1353 / 1359

Location

United States

Related Subject Headings

  • Physical Fitness
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Health Status Indicators
  • Geriatrics
  • Geriatric Assessment
  • Gait
  • Female