Cardiovascular Metabolomics.

Published

Journal Article (Review)

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studies have contributed to better understanding of the metabolic changes that occur in heart failure and ischemic heart disease and have identified new cardiovascular disease biomarkers. As technologies advance, the metabolomics field continues to evolve rapidly. In this review, we will discuss the current state of metabolomics technologies, including consideration of various metabolomics platforms and elements of study design; the emerging utility of stable isotopes for metabolic flux studies; and the use of metabolomics to better understand specific cardiovascular diseases, with an emphasis on recent advances in the field.

Full Text

Duke Authors

Cited Authors

  • McGarrah, RW; Crown, SB; Zhang, G-F; Shah, SH; Newgard, CB

Published Date

  • April 27, 2018

Published In

Volume / Issue

  • 122 / 9

Start / End Page

  • 1238 - 1258

PubMed ID

  • 29700070

Pubmed Central ID

  • 29700070

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.117.311002

Language

  • eng

Conference Location

  • United States