Investigating Predictors of Cognitive Decline Using Machine Learning.

Journal Article (Journal Article)

OBJECTIVES: Genetic risks for cognitive decline are not modifiable; however their relative importance compared to modifiable factors is unclear. We used machine learning to evaluate modifiable and genetic risk factors for Alzheimer's disease (AD), to predict cognitive decline. METHODS: Health and Retirement Study participants, aged 65-90 years, with DNA and >2 cognitive evaluations, were included (n = 7,142). Predictors included age, body mass index, gender, education, APOE ε4, cardiovascular, hypertension, diabetes, stroke, neighborhood socioeconomic status (NSES), and AD risk genes. Latent class trajectory analyses of cognitive scores determined the form and number of classes. Random Forests (RF) classification investigated predictors of cognitive trajectories. Performance metrics (accuracy, sensitivity, and specificity) were reported. RESULTS: Three classes were identified. Discriminating highest from lowest classes produced the best RF performance: accuracy = 78% (1.0%), sensitivity = 75% (1.0%), and specificity = 81% (1.0%). Top ranked predictors were education, age, gender, stroke, NSES, and diabetes, APOE ε4 carrier status, and body mass index (BMI). When discriminating high from medium classes, top predictors were education, age, gender, stroke, diabetes, NSES, and BMI. When discriminating medium from the low classes, education, NSES, age, diabetes, and stroke were top predictors. DISCUSSION: The combination of latent trajectories and RF classification techniques suggested that nongenetic factors contribute more to cognitive decline than genetic factors. Education was the most relevant predictor for discrimination.

Full Text

Duke Authors

Cited Authors

  • Casanova, R; Saldana, S; Lutz, MW; Plassman, BL; Kuchibhatla, M; Hayden, KM

Published Date

  • March 9, 2020

Published In

Volume / Issue

  • 75 / 4

Start / End Page

  • 733 - 742

PubMed ID

  • 29718387

Pubmed Central ID

  • PMC7205421

Electronic International Standard Serial Number (EISSN)

  • 1758-5368

Digital Object Identifier (DOI)

  • 10.1093/geronb/gby054


  • eng

Conference Location

  • United States