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Generalized Periodic Discharges: A Topical Review.

Publication ,  Journal Article
Sully, KE; Husain, AM
Published in: J Clin Neurophysiol
May 2018

Generalized periodic discharges (GPDs) are generalized discharges that recur with a relatively uniform morphology and duration. They have a quantifiable interdischarge interval. Over the past decade, our understanding of these waveforms has improved considerably. The nomenclature has changed, and etiologic references have been removed. Many disease states can cause GPDs, such as anoxia, toxic/metabolic encephalopathy, infections, nonconvulsive status epilepticus, and hypothermia. Generally, GPDs are morphologically similar regardless of etiology. Generalized periodic discharges that are associated with nonconvulsive status epilepticus are treated with antiseizure drugs, while others are not necessarily aggressively treated. Prognosis for most patients with GPDs is guarded, although this is also dependent on the underlying etiology. As our understanding of GPDs increases, it is also clear that there is much more to be learned about these waveforms.

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Published In

J Clin Neurophysiol

DOI

EISSN

1537-1603

Publication Date

May 2018

Volume

35

Issue

3

Start / End Page

199 / 207

Location

United States

Related Subject Headings

  • Terminology as Topic
  • Periodicity
  • Neurology & Neurosurgery
  • Nervous System Diseases
  • Humans
  • Electroencephalography
  • Brain
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

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Sully, K. E., & Husain, A. M. (2018). Generalized Periodic Discharges: A Topical Review. J Clin Neurophysiol, 35(3), 199–207. https://doi.org/10.1097/WNP.0000000000000460
Sully, Krystal E., and Aatif M. Husain. “Generalized Periodic Discharges: A Topical Review.J Clin Neurophysiol 35, no. 3 (May 2018): 199–207. https://doi.org/10.1097/WNP.0000000000000460.
Sully KE, Husain AM. Generalized Periodic Discharges: A Topical Review. J Clin Neurophysiol. 2018 May;35(3):199–207.
Sully, Krystal E., and Aatif M. Husain. “Generalized Periodic Discharges: A Topical Review.J Clin Neurophysiol, vol. 35, no. 3, May 2018, pp. 199–207. Pubmed, doi:10.1097/WNP.0000000000000460.
Sully KE, Husain AM. Generalized Periodic Discharges: A Topical Review. J Clin Neurophysiol. 2018 May;35(3):199–207.

Published In

J Clin Neurophysiol

DOI

EISSN

1537-1603

Publication Date

May 2018

Volume

35

Issue

3

Start / End Page

199 / 207

Location

United States

Related Subject Headings

  • Terminology as Topic
  • Periodicity
  • Neurology & Neurosurgery
  • Nervous System Diseases
  • Humans
  • Electroencephalography
  • Brain
  • 5203 Clinical and health psychology
  • 5202 Biological psychology
  • 3209 Neurosciences