Earth BioGenome Project: Sequencing life for the future of life.

Journal Article (Journal Article)

Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort.

Full Text

Duke Authors

Cited Authors

  • Lewin, HA; Robinson, GE; Kress, WJ; Baker, WJ; Coddington, J; Crandall, KA; Durbin, R; Edwards, SV; Forest, F; Gilbert, MTP; Goldstein, MM; Grigoriev, IV; Hackett, KJ; Haussler, D; Jarvis, ED; Johnson, WE; Patrinos, A; Richards, S; Castilla-Rubio, JC; van Sluys, M-A; Soltis, PS; Xu, X; Yang, H; Zhang, G

Published Date

  • April 24, 2018

Published In

Volume / Issue

  • 115 / 17

Start / End Page

  • 4325 - 4333

PubMed ID

  • 29686065

Pubmed Central ID

  • PMC5924910

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.1720115115


  • eng

Conference Location

  • United States