Progress in Understanding and Treating SCN2A-Mediated Disorders.
Advances in gene discovery for neurodevelopmental disorders have identified SCN2A dysfunction as a leading cause of infantile seizures, autism spectrum disorder, and intellectual disability. SCN2A encodes the neuronal sodium channel NaV1.2. Functional assays demonstrate strong correlation between genotype and phenotype. This insight can help guide therapeutic decisions and raises the possibility that ligands that selectively enhance or diminish channel function may improve symptoms. The well-defined function of sodium channels makes SCN2A an important test case for investigating the neurobiology of neurodevelopmental disorders more generally. Here, we discuss the progress made, through the concerted efforts of a diverse group of academic and industry scientists as well as policy advocates, in understanding and treating SCN2A-related disorders.
Duke Scholars
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Related Subject Headings
- Neurology & Neurosurgery
- Neurodevelopmental Disorders
- NAV1.2 Voltage-Gated Sodium Channel
- Humans
- Animals
- 5203 Clinical and health psychology
- 5202 Biological psychology
- 3209 Neurosciences
- 1702 Cognitive Sciences
- 1701 Psychology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Neurology & Neurosurgery
- Neurodevelopmental Disorders
- NAV1.2 Voltage-Gated Sodium Channel
- Humans
- Animals
- 5203 Clinical and health psychology
- 5202 Biological psychology
- 3209 Neurosciences
- 1702 Cognitive Sciences
- 1701 Psychology