Nursing clinical practice guidelines have been developed to assist nurses' care processes, but these clinical guidelines have not been used effectively in practice. In order to use clinical practice guidelines effectively at the point of care, they should be represented in a computer interpretable format. To facilitate the use of nursing guidelines, this pilot study explored the feasibility of developing a computer interpretable guideline (CIG) using a guideline modeling language with nursing guideline content. Pressure ulcer risk assessments and the related procedures and protocols available at a local hospital were encoded with Guideline Interchange Format (GLIF). A CIG was developed and was validated for its accuracy of the knowledge translated into a CIG using 30 patient scenarios. Findings of this study showed that it is feasible to encode a nursing guideline using a guideline modeling language and that a CIG can be developed for a computerized decision support system. © 2013 OJNI.