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Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice.

Publication ,  Journal Article
Jin, Y; Zhang, C; Wang, H; Zhou, G; Wang, X; Zhang, R; Chen, S; Ren, J; Chen, L; Dang, D; Zhang, P; Xi, Y; Wu, W; Zhang, W; Duan, G
Published in: Lab Invest
August 2018

Enterovirus (EV) 71 infection has been widely acknowledged as the leading cause of severe hand, foot and mouth disease (HFMD), which may rapidly lead to fatal pulmonary edema. In this study, we established a mouse model for EV71 infection exhibiting high incidence of severe symptoms with pulmonary edema. Mast cells (MCs) accumulation, activation and allergic inflammation were found in the brains, lungs and skeletal muscle of mice after EV71 infection, especially in the lungs of mice. Levels of histamine, platelet-activating factor (PAF), interleukin (IL)-4, IL-5, IL-13, tumor necrosis factor-α (TNF-α), nitric oxide (NO), endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and noradrenaline (NA) were increased in EV71-infected lungs. In addition, EV71 infection reduced the number of pulmonary T cells, dendritic cells (DCs) and monocytes, and increased the number of lung eosinophils, Tregs and MCs. MCs number and tryptase expression in target organs or tissues posed a trend towards an increase from control to severe mice. There were positive correlations between MCs number in the brains (r = 0.701, P = 0.003), lungs (r = 0.802, P < 0.0001), skeletal muscles (r = 0.737, P = 0.001) and mean clinical score. Thus, our results suggested that MCs contributed to the pulmonary edema during EV71 infection.

Duke Scholars

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Published In

Lab Invest

DOI

EISSN

1530-0307

Publication Date

August 2018

Volume

98

Issue

8

Start / End Page

1039 / 1051

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Pulmonary Edema
  • Pathology
  • Muscle, Skeletal
  • Mice, Inbred BALB C
  • Mast Cells
  • Lung
  • Humans
  • Histamine
  • Enterovirus Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jin, Y., Zhang, C., Wang, H., Zhou, G., Wang, X., Zhang, R., … Duan, G. (2018). Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice. Lab Invest, 98(8), 1039–1051. https://doi.org/10.1038/s41374-018-0075-y
Jin, Yuefei, Chao Zhang, Hui Wang, Guangyuan Zhou, Xiangpeng Wang, Rongguang Zhang, Shuaiyin Chen, et al. “Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice.Lab Invest 98, no. 8 (August 2018): 1039–51. https://doi.org/10.1038/s41374-018-0075-y.
Jin Y, Zhang C, Wang H, Zhou G, Wang X, Zhang R, et al. Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice. Lab Invest. 2018 Aug;98(8):1039–51.
Jin, Yuefei, et al. “Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice.Lab Invest, vol. 98, no. 8, Aug. 2018, pp. 1039–51. Pubmed, doi:10.1038/s41374-018-0075-y.
Jin Y, Zhang C, Wang H, Zhou G, Wang X, Zhang R, Chen S, Ren J, Chen L, Dang D, Zhang P, Xi Y, Wu W, Zhang W, Duan G. Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice. Lab Invest. 2018 Aug;98(8):1039–1051.

Published In

Lab Invest

DOI

EISSN

1530-0307

Publication Date

August 2018

Volume

98

Issue

8

Start / End Page

1039 / 1051

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Pulmonary Edema
  • Pathology
  • Muscle, Skeletal
  • Mice, Inbred BALB C
  • Mast Cells
  • Lung
  • Humans
  • Histamine
  • Enterovirus Infections