Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.

Published

Journal Article

Background:Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31. Methods:To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls. Results:We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges. Conclusions:This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.

Full Text

Duke Authors

Cited Authors

  • Claus, EB; Cornish, AJ; Broderick, P; Schildkraut, JM; Dobbins, SE; Holroyd, A; Calvocoressi, L; Lu, L; Hansen, HM; Smirnov, I; Walsh, KM; Schramm, J; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Swerdlow, A; Larsen, SB; Johansen, C; Simon, M; Bondy, M; Wrensch, M; Houlston, RS; Wiemels, JL

Published Date

  • October 2018

Published In

Volume / Issue

  • 20 / 11

Start / End Page

  • 1485 - 1493

PubMed ID

  • 29762745

Pubmed Central ID

  • 29762745

Electronic International Standard Serial Number (EISSN)

  • 1523-5866

International Standard Serial Number (ISSN)

  • 1523-5866

Digital Object Identifier (DOI)

  • 10.1093/neuonc/noy077

Language

  • eng