Cooling the Itch via TRPM8.


Journal Article

Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et al. demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch, suggesting that pharmacologic TRPM8 activation should be explored further as an antipruritic strategy.

Full Text

Duke Authors

Cited Authors

  • Liu, B; Jordt, S-E

Published Date

  • June 2018

Published In

Volume / Issue

  • 138 / 6

Start / End Page

  • 1254 - 1256

PubMed ID

  • 29793621

Pubmed Central ID

  • 29793621

Electronic International Standard Serial Number (EISSN)

  • 1523-1747

Digital Object Identifier (DOI)

  • 10.1016/j.jid.2018.01.020


  • eng

Conference Location

  • United States