Electrochemistry of redox-active Mn porphyrin-based SOD mimic MnTnBuOE-2-PyP5+ - study of redox species involved in ROS/RNS scavenging


Journal Article

© 2014 by the authors; licensee IAPC, Zagreb, Croatia. Manganese ortho tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, is a third-generation redox-active compound currently undergoing preclinical exploration. This work is intended to complement the already extensive research of its chemical and biological properties by a simple electrochemical study. The thermodynamic parameters related to the Mn(IV) porphyrin species of MnTnBuOE-2-PyP5+ determined in this work support its observed reactivity as an efficient scavenger of peroxynitrite. The corresponding driving forces for the possible single-electron or two-electron reductions of ONOO- have been estimated as well.

Full Text

Duke Authors

Cited Authors

  • Weitner, T; Batinic-Haberle, I

Published Date

  • September 1, 2014

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 185 - 190

Electronic International Standard Serial Number (EISSN)

  • 1848-7718

Digital Object Identifier (DOI)

  • 10.5599/admet.2.3.123

Citation Source

  • Scopus